A competitive inhibitor interacts with the free enzyme to form an enzyme•inhibitor complex (E•I). This equilibrium reaction can be described as follows: E + I ⇌ EI Modify the simplified kinetic scheme for the reaction E + S ⇌ E + P to include this equilibrium expression
A competitive inhibitor interacts with the free enzyme to form an enzyme•inhibitor complex
(E•I). This equilibrium reaction can be described as follows:
E + I ⇌ EI
Modify the simplified kinetic scheme for the reaction E + S ⇌ E + P to include this equilibrium
expression
Enzyme inhibition is a process by which the activity of an enzyme is altered. Inhibitors are substances that decreases the catalytic activity of an enzyme by altering the interaction between the enzyme & substrate.
Enzyme inhibition can be classified into the following types:
- Reversible
- Irreversible
The reversible enzyme inhibition can be categorized into the following types:
- Competitive
- Non-Competitive
- Uncompetitive
Km indicates the Michaelis constant & Vmax (Vm) refers to the maximum velocity attained by the reaction. E refers to the Enzyme, S refers to the substrate, P refers to the product & I refer to the inhibitor.
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