A chemist synthesizes four new chemical compounds in the laboratory and names them PFI1, PFI2, PFI3, and PFI4. He gives the PFI compounds to a geneticist friend and asks her to determine their mutagenic potential. The geneticist finds that all four are highly mutagenic. She also tests the capacity of mutations produced by the PFI compounds to be reversed by other known mutagens and obtains the following results. What conclusions can you make about the nature of the mutations produced by these compounds? Reversed by Mutations, Nitrous, Aminopurine acid Acridine orange 2- produced by Hydroxylamine PFI1 Yes Yes Some No PFI2 No No No No PFI3 Yes Yes No No PFI4 No No No Yes
A chemist synthesizes four new chemical compounds in the laboratory and names them PFI1, PFI2, PFI3, and PFI4. He gives the PFI compounds to a geneticist friend and asks her to determine their mutagenic potential. The geneticist finds that all four are highly mutagenic. She also tests the capacity of mutations produced by the PFI compounds to be reversed by other known mutagens and obtains the following results. What conclusions can you make about the nature of the mutations produced by these compounds? Reversed by Mutations, Nitrous, Aminopurine acid Acridine orange 2- produced by Hydroxylamine PFI1 Yes Yes Some No PFI2 No No No No PFI3 Yes Yes No No PFI4 No No No Yes
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:A chemist synthesizes four new chemical compounds in the laboratory
and names them PFI1, PFI2, PFI3, and PFI4. He gives the PFI
compounds to a geneticist friend and asks her to determine their
mutagenic potential. The geneticist finds that all four are highly
mutagenic. She also tests the capacity of mutations produced by the PFI
compounds to be reversed by other known mutagens and obtains the
following results. What conclusions can you make about the nature of
the mutations produced by these compounds?
Reversed by
Mutations,
Nitrous,
Aminopurine acid
Acridine
orange
2-
produced
by
Hydroxylamine
PFI1
Yes
Yes
Some
No
PFI2
No
No
No
No
PFI3
Yes
Yes
No
No
PFI4
No
No
No
Yes
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