Answered: (a) (c) 1/v + inhibitor 1/[S] (b) +…

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Biochemistry

(a) (c) 1/v + inhibitor 1/[S] (b) + inhibitor X 1/v 1/[S] + inhibitor + inhibitor (d) 1/v 1/V I i 1/[S] 1/[S]

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

The rate of an enzyme-catalysed reaction was measured in the absence or presence of a non-competitive inhibitor. Which of the following Lineweaver-Burk plots would you expect to see?

a. (a)

b. (b)

c. (c)

d. (d)

(a)
(c)
1/v
1/v
+ inhibitor
1/[S]
+ inhibitor
1/[S]
(b)
(d)
+ inhibitor
1/v
1/[S]
+ inhibitor
1/v
1/[S]

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Understanding non competitive inhibition

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Lineweaver-Burk plot of non competitive inhibition

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