A B C F G H E Chromosome 1 N P Q R S KL M Chromosome 2 10. The image above shows two normal chromosomes. Use the image above to indicate what type of chromosomal rearrangement occurred to result in the following changes. a. Chromosome 1 ABCDEI Chromosome 2 unchanged b. Chromosome 1 A B C D E PQRS Chromosome 2 JK LM NOFGHI c. Chromosome 1 unchanged Chromosome 2 JKL MNR Q POS d. Chromosome 1 unchanged Chromosome 2 JK L M NOOPQ RRS
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Chromosomal abnormalities refer to changes in chromosomal number (numerical abnormality) or structure (structural abnormality).
Numerical abnormality refers to increase or decrease in the number of chromosomes in a cell. It can be found in somatic or germ cells.
Structural abnormality refers to alteration in the structure of chromosomes. It includes deletion (a segment from a chromosome is missing), inversion (a segment of chromosome is broken and gets reattached to same chromosome but with inverted arrangement of genes), duplication (a segment of chromosome gets duplicated), translocation ( a segment of chromosome is translocated from one chromosome to another) and insertion (a segment of chromosome is broken and gets attached to other chromosome)
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