7. A thumb on the balance. The reaction catalyzed by phos- phorylase is readily reversible in vitro. At pH 6.8, the equi- librium ratio of orthophosphate to glucose 1-phosphate is 3.6. The value of AG°' for this reaction is small because a glycosidic bond is replaced by a phosphoryl ester bond that has a nearly equal transfer potential. However, phospho- rolysis proceeds far in the direction of glycogen breakdown in vivo. Suggest one means by which the reaction can be made irreversible in vivo.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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7. 

7. A thumb on the balance. The reaction catalyzed by phos-
phorylase is readily reversible in vitro. At pH 6.8, the equi-
librium ratio of orthophosphate to glucose 1-phosphate is
3.6. The value of AG°' for this reaction is small because a
glycosidic bond is replaced by a phosphoryl ester bond that
has a nearly equal transfer potential. However, phospho-
rolysis proceeds far in the direction of glycogen breakdown
in vivo. Suggest one means by which the reaction can be
made irreversible in vivo.
Transcribed Image Text:7. A thumb on the balance. The reaction catalyzed by phos- phorylase is readily reversible in vitro. At pH 6.8, the equi- librium ratio of orthophosphate to glucose 1-phosphate is 3.6. The value of AG°' for this reaction is small because a glycosidic bond is replaced by a phosphoryl ester bond that has a nearly equal transfer potential. However, phospho- rolysis proceeds far in the direction of glycogen breakdown in vivo. Suggest one means by which the reaction can be made irreversible in vivo.
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