7) the amino acid below attached to PLP as an imine. Hydrolyze the product amino acid off with water. Don't worry about stereochemistry. Show how PLP can carry out the following conversion. Start the mechanism with PLP, H20 H NH3 CO2H + PI NH2 H OH

7) the amino acid below attached to PLP as an imine. Hydrolyze the product amino acid off with water. Don't worry about stereochemistry. Show how PLP can carry out the following conversion. Start the mechanism with PLP, H20 H NH3 CO2H + PI NH2 H OH

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

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7)
the amino acid below attached to PLP as an imine. Hydrolyze the product amino acid off with
water. Don't worry about stereochemistry.
Show how PLP can carry out the following conversion. Start the mechanism with
PLP, H20
NH3
.Co,H
+ Pi
CO2
OH
NH2

Expert Solution

Step 1

PLP or Pyridoxal phosphate is an enzyme which has the ability to act as an electrophilic catalyst that stabilizes different types of carbanionic reaction intermediates. It catalyzes myriad reactions and forms internal lysine derived aldimine.

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