6. The following transformation occurs by a sequence of two reactions. First a conjugate substitution occurs then a nucleophilic aromatic substitution. F OEt NH₂ NEt3 heat (A) Propose a mechanism for this transformation. OEt (B) Propose why the conjugate substitution occurs prior to the nucleophilic aromatic substitution rather than the other way around. (C) Predict if the nucleophilic aromatic substitution would proceed better or worse if an iodide was used instead of the fluoride as a leaving group.
6. The following transformation occurs by a sequence of two reactions. First a conjugate substitution occurs then a nucleophilic aromatic substitution. F OEt NH₂ NEt3 heat (A) Propose a mechanism for this transformation. OEt (B) Propose why the conjugate substitution occurs prior to the nucleophilic aromatic substitution rather than the other way around. (C) Predict if the nucleophilic aromatic substitution would proceed better or worse if an iodide was used instead of the fluoride as a leaving group.
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:6. The following transformation occurs by a sequence of two reactions. First a
conjugate substitution occurs then a nucleophilic aromatic substitution.
NH₂
F
y I
OEt
NEt3
heat
(A) Propose a mechanism for this transformation.
`N
OEt
(B) Propose why the conjugate substitution occurs prior to the nucleophilic
aromatic substitution rather than the other way around.
(C) Predict if the nucleophilic aromatic substitution would proceed better or worse
if an iodide was used instead of the fluoride as a leaving group.
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