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6. Haemophilia is a relatively uncommon, sex-linked condition that is determined by a recessive allele on the X chromosome. It is a condition in humans in which the blood fails to clot normally. The following diagram shows a pedigree for haemophilia. Joe Sally Tom 1 Jim Sheila 2 3 ? Tina Mary Barry 4 5 6 7 Affected male Unaffected male Affected female Unaffected female a) Determine the possible genotypes for Jim, Sheila and their children (Sally, Tom and Mary). Use the symbols XH for the normal allele and Xh for the mutant allele and Y for the Y chromosome. Briefly state your logic in each case. b) Tom and Tina are expecting their first child and want to know the probability that the child had haemophilia i) if it is a boy or ii) if it is a girl. How would you advise them?

6. Haemophilia is a relatively uncommon, sex-linked condition that is determined by a recessive allele on the X chromosome. It is a condition in humans in which the blood fails to clot normally. The following diagram shows a pedigree for haemophilia. Joe Sally Tom 1 Jim Sheila 2 3 ? Tina Mary Barry 4 5 6 7 Affected male Unaffected male Affected female Unaffected female a) Determine the possible genotypes for Jim, Sheila and their children (Sally, Tom and Mary). Use the symbols XH for the normal allele and Xh for the mutant allele and Y for the Y chromosome. Briefly state your logic in each case. b) Tom and Tina are expecting their first child and want to know the probability that the child had haemophilia i) if it is a boy or ii) if it is a girl. How would you advise them?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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6. Haemophilia is a relatively uncommon, sex-linked condition that is determined by a recessive allele on the X chromosome. It is a condition in humans in which the blood fails to clot normally. The following diagram shows a pedigree for haemophilia. Joe Sally Tom Tina 1 Jim Sheila 2 3 ? Mary Barry 4 5 6 7 Affected male Unaffected male Affected female Unaffected female a) Determine the possible genotypes for Jim, Sheila and their children (Sally, Tom and Mary). Use the symbols XH for the normal allele and Xh for the mutant allele and Y for the Y chromosome. Briefly state your logic in each case. b) Tom and Tina are expecting their first child and want to know the probability that the child had haemophilia i) if it is a boy or ii) if it is a girl. How would you advise them?
Transcribed Image Text:6. Haemophilia is a relatively uncommon, sex-linked condition that is determined by a recessive allele on the X chromosome. It is a condition in humans in which the blood fails to clot normally. The following diagram shows a pedigree for haemophilia. Joe Sally Tom Tina 1 Jim Sheila 2 3 ? Mary Barry 4 5 6 7 Affected male Unaffected male Affected female Unaffected female a) Determine the possible genotypes for Jim, Sheila and their children (Sally, Tom and Mary). Use the symbols XH for the normal allele and Xh for the mutant allele and Y for the Y chromosome. Briefly state your logic in each case. b) Tom and Tina are expecting their first child and want to know the probability that the child had haemophilia i) if it is a boy or ii) if it is a girl. How would you advise them?
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