↓ 4. Predict what mode of action this antibiotic might use to kill the bacterial cell. You decide to test the new drug to see what mode of action the drug might use. You set up two sets of broths: one set you will allow to grow as a control; to the other broth, you add your new drug. You then take several measurements to attempt to determine the mode of action. Below are the measurements you make: ▪ Radioactive thymine incorporation (Figure 1) ▪ Radioactive methionine incorporation (Figure 2) ▪ Radioactive uracil incorporation (Figure 3) ▪ Glucose depletion (Figure 4) ▪ DNA present in the broth (Figure 5)
↓ 4. Predict what mode of action this antibiotic might use to kill the bacterial cell. You decide to test the new drug to see what mode of action the drug might use. You set up two sets of broths: one set you will allow to grow as a control; to the other broth, you add your new drug. You then take several measurements to attempt to determine the mode of action. Below are the measurements you make: ▪ Radioactive thymine incorporation (Figure 1) ▪ Radioactive methionine incorporation (Figure 2) ▪ Radioactive uracil incorporation (Figure 3) ▪ Glucose depletion (Figure 4) ▪ DNA present in the broth (Figure 5)
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter6: Safe Dosage Calculations
Section: Chapter Questions
Problem B.4CRQ
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Transcribed Image Text:↓
4. Predict what mode of action this antibiotic might use to kill the bacterial cell. You decide to test the
new drug to see what mode of action the drug might use. You set up two sets of broths: one set you will
allow to grow as a control; to the other broth, you add your new drug. You then take several
measurements
to attempt to determine the mode of action. Below are the measurements you make:
▪ Radioactive thymine incorporation (Figure 1)
▪ Radioactive methionine incorporation (Figure 2)
▪ Radioactive uracil incorporation (Figure 3)
▪ Glucose depletion (Figure 4)
DNA present in the broth (Figure 5) ©
■
Transcribed Image Text:Po
~Av
Αν
Radioactive Thymine
(գլոսյա/siunos)
500
400-
300-
200-
100-
Radioactive Uracil
(counts/minute)
Figure 1- Radioactive Thymine
E-621 3¶
= = = = 112
0-
100
80-
60-
40-
20
15
20
Time (minutes)
Figure 3-Radioactive Uracil
1
1
0-
14
ted States) IT
1
5
10
5
2
10
25
25
20
15
Time (minutes)
1
30
111111
30
V
g
DNA in broth
35
2-
1.5-
1-
0.5-
0
3
35
Test broth with antibiotic added
Control broth with no antibiotic added
1
V
40
glucose concentration to kill the bacteria.
40
Figure 5-DNA in the Broth
2.5-
5
L
AaBbCcDdEe AaBbCcDdEe AaBb AaBbC
Normal
No Spacing
Heading 1
Heading 2
Radioactive Methionine
10
(counts/minute)
30,000
25,000-
20,000-
15,000-
Figure 2- Radioactive Methionine
10,000-
5,000-
0++
500-
400-
300-
200-
100-
Figure 4- Glucose Concentration
0
25
1
15 20
Time (minutes)
LL
MacBook Pro
1
30
5
5
f
5
35
W
20 25
15
10
Time (minutes)
10
40
6
LI
25
15 20
Time (minutes)
30
30
35
35
40
40
Foc
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