4. Normal yeast cells can survive on a diet of sugars, a few simple salts and one vitamin. They can make all of their amino acids and other vitamins using what can be found in their diet. You identify a mutant strain that can only survive if given alanine, which is one of the amino acids. The mutation is recessive. Based on this information, what would you predict that the normal function of the dominant allele is?

4. Normal yeast cells can survive on a diet of sugars, a few simple salts and one vitamin. They can make all of their amino acids and other vitamins using what can be found in their diet. You identify a mutant strain that can only survive if given alanine, which is one of the amino acids. The mutation is recessive. Based on this information, what would you predict that the normal function of the dominant allele is?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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The Joneses were referred to a clinical geneticist because their 6-month-old daughter was failing to grow adequately and was having recurrent infections. The geneticist took a detailed family history (which was uninformative) and a medical history of their daughter. He discovered that their daughter had a history of a constant cough and wheeze that was becoming progressively worse, had difficulty gaining weight (failure to thrive), and had an extensive history of yeast infection (thrush) in her mouth. The geneticist did a simple blood test to check their daughters white blood count and determined that she had severe combined immunodeficiency (SCID). The geneticist explained that SCID is an immune deficiency that causes a marked susceptibility to infections. The defining characteristic is usually a severe defect in both the T- and B-lymphocyte systems. This results in one or more infections within the first few months of life that are serious and may even be life-threatening. Based on the family history, it was possible that their daughter had inherited a mutant allele from each of them and therefore was homozygous for a gene that causes SCID. If so, each time the Joneses had a child, there would be a 25% chance that the child would have SCID. Prenatal testing is available to determine whether the developing fetus has SCID. If the Joneses want to be certain that their next child will not have SCID, what types of reproductive options do you think they have?
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