4. Given the net glomerular filtration pressure of 55 mm Hg, a plasma protein osmotic force (TTGC) = 12 mm Hg, and a fluid pressure in Bowman's space (PBS) = 10 mm Hg, what would be glomerular capillary blood pressure (PGC)? Would filtration be favored under these conditions? How do you know?
4. Given the net glomerular filtration pressure of 55 mm Hg, a plasma protein osmotic force (TTGC) = 12 mm Hg, and a fluid pressure in Bowman's space (PBS) = 10 mm Hg, what would be glomerular capillary blood pressure (PGC)? Would filtration be favored under these conditions? How do you know?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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Transcribed Image Text:4. Given the net glomerular filtration pressure of 55 mm Hg, a plasma protein osmotic force
(TTGC) = 12 mm Hg, and a fluid pressure in Bowman's space (PBS) = 10 mm Hg, what would be
glomerular capillary blood pressure (PGC)? Would filtration be favored under these conditions?
How do you know?
Expert Solution
Step 1: Terms and their significance in the context of renal physiology
Terms and their significance in the context of renal physiology:
Net Glomerular Filtration Pressure (NFP):
- NFP is the pressure gradient driving glomerular filtration in the kidneys.
- Calculated as the difference between glomerular capillary blood pressure (PGc) and the sum of plasma protein osmotic force (PGC) and fluid pressure in Bowman's space (PBS).
- Positive NFP favors filtration, while negative NFP hinders it.
Plasma Protein Osmotic Force (PGC):
- Created by proteins in blood plasma, especially albumin.
- Opposes filtration by drawing fluid back into glomerular capillaries.
Fluid Pressure in Bowman's Space (PBS):
- Hydrostatic pressure from fluid in Bowman's space.
- Promotes filtration by pushing fluid into Bowman's capsule.
Glomerular Capillary Blood Pressure (PGc):
- Pressure within glomerular capillaries.
- Drives fluid and solute filtration into Bowman's space.
NFP Calculation:
- NFP = PGc - (PGC + PBS)
- Positive NFP: Filtration favored, typical in normal conditions.
- Negative NFP: Filtration reduced or reversed, seen in certain pathologies.
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