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3D. Traditional Friedel Crafts acylation reactions often use water sensitive reagents and produce toxic products like hydrochloric acid, as described in the experiment provided in this module. Recently, work has been done to utilize biological enzymes to prepare the acyl group for substitution rather than the harsh reaction of aluminum chloride and acetyl chloride. In the link below, they describe using isopropenyl acetate as the acyl source. This will allow reactions to proceed in more environmentally friendly aqueous solvent systems and produce a more benign biproduct, acetone. https://www.nature.com/articles/s41929-019-0262-2 What are the products of the reaction of acetyl chloride and water? Include a comment about whether the reaction is exothermic or endothermic and how this may factor into the safety issues of using acetyl chloride. https://www.chemguide.co.uk/mechanisms/addelim/water.html

3D. Traditional Friedel Crafts acylation reactions often use water sensitive reagents and produce toxic products like hydrochloric acid, as described in the experiment provided in this module. Recently, work has been done to utilize biological enzymes to prepare the acyl group for substitution rather than the harsh reaction of aluminum chloride and acetyl chloride. In the link below, they describe using isopropenyl acetate as the acyl source. This will allow reactions to proceed in more environmentally friendly aqueous solvent systems and produce a more benign biproduct, acetone. https://www.nature.com/articles/s41929-019-0262-2 What are the products of the reaction of acetyl chloride and water? Include a comment about whether the reaction is exothermic or endothermic and how this may factor into the safety issues of using acetyl chloride. https://www.chemguide.co.uk/mechanisms/addelim/water.html

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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### Experiment 3D: Friedel-Crafts Acylation Reactions Traditional Friedel-Crafts acylation reactions often employ water-sensitive reagents and generate toxic by-products such as hydrochloric acid. This is observed in the experiment outlined in this module. Recent advancements focus on utilizing biological enzymes to prepare acyl groups for substitution, thereby avoiding the harsh reaction of aluminum chloride and acetyl chloride. The study referenced in the link below discusses the use of isopropenyl acetate as the acyl source. This method permits reactions to occur in more environmentally friendly aqueous solvent systems and produces a more benign byproduct, acetone. For detailed information, you can access the study here: [https://www.nature.com/articles/s41929-019-0262-2](https://www.nature.com/articles/s41929-019-0262-2) ### Safety Analysis: Reaction of Acetyl Chloride and Water Consider the reaction products of acetyl chloride when it comes into contact with water. Additionally, assess whether the reaction is exothermic or endothermic, paying attention to the implications for the safe handling of acetyl chloride. You can explore the detailed reaction mechanism at: [https://www.chemguide.co.uk/mechanisms/addelim/water.html](https://www.chemguide.co.uk/mechanisms/addelim/water.html) ### Discussion Points: - Comparison of the environmental and safety impacts of traditional vs. enzyme-mediated acylation. - Chemical and environmental significance of byproducts like hydrochloric acid vs. acetone. - Energy considerations in the reaction processes and their implications for laboratory safety. This content will help students understand the environmental and safety considerations in chemical synthesis, particularly focusing on the Friedel-Crafts acylation reactions.
Transcribed Image Text:### Experiment 3D: Friedel-Crafts Acylation Reactions Traditional Friedel-Crafts acylation reactions often employ water-sensitive reagents and generate toxic by-products such as hydrochloric acid. This is observed in the experiment outlined in this module. Recent advancements focus on utilizing biological enzymes to prepare acyl groups for substitution, thereby avoiding the harsh reaction of aluminum chloride and acetyl chloride. The study referenced in the link below discusses the use of isopropenyl acetate as the acyl source. This method permits reactions to occur in more environmentally friendly aqueous solvent systems and produces a more benign byproduct, acetone. For detailed information, you can access the study here: [https://www.nature.com/articles/s41929-019-0262-2](https://www.nature.com/articles/s41929-019-0262-2) ### Safety Analysis: Reaction of Acetyl Chloride and Water Consider the reaction products of acetyl chloride when it comes into contact with water. Additionally, assess whether the reaction is exothermic or endothermic, paying attention to the implications for the safe handling of acetyl chloride. You can explore the detailed reaction mechanism at: [https://www.chemguide.co.uk/mechanisms/addelim/water.html](https://www.chemguide.co.uk/mechanisms/addelim/water.html) ### Discussion Points: - Comparison of the environmental and safety impacts of traditional vs. enzyme-mediated acylation. - Chemical and environmental significance of byproducts like hydrochloric acid vs. acetone. - Energy considerations in the reaction processes and their implications for laboratory safety. This content will help students understand the environmental and safety considerations in chemical synthesis, particularly focusing on the Friedel-Crafts acylation reactions.
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