3. Which of the following could lead to increased risk of developing Alzheimer's Disease? A. hypermorphic mutation a-secretase B. hypermorphic mutation B-secretase C. hypermorphic mutation y-secretase D. both A and B E. both B and C
Answer all 3,4,5.choose correct option and no need to explain long just explain shortly. Thanks
3. Which of the following could lead to increased risk of developing Alzheimer's Disease?
A. hypermorphic mutation a-secretase
B. hypermorphic mutation B-secretase
C. hypermorphic mutation y-secretase
D. both A and B
E. both B and C
4. In the Sonic Hedgehog signaling pathway, which of the following would promote stem cell differentiation?
A. loss of function mutation in GLI1
B. genetic knock-out of SUFU C. hypomorphic mutation of SMO
D. over-expression of Shh ligand
5.Using the CRISPR/Cas9 system, a genetically-engineered sgRNA complementary to a target alte in the genome binds to Cas9 endonuclease. A mutation can occur at this site when
A Cas9 cleaves the DNA and nonhomologous end-joining results in a small deletion.
B. Cas9 cleaves the DNA and homologous recombination with the homologous chromosome is used to repair the break.
C. Cas9 cleaves the DNA and nonhomologous end-joining correctly repairs the break.
D. All of the above
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