3. Using curved arrows, draw the mechanism of both steps involved in the synthesis of isoxazole (5). Why is a base (triethyl amine) required in the first step of the pathway? What is the byproduct (4) of this step? NH2 CI. -NH H3C- -Ph H3C- -CH3 + 1 2 3 4 Robinson H3PO4 Gabriel -N + H20 H3C- -CH3 5

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Solve Q3 and Q4 with detailed expalantion 

3. Using curved arrows, draw the mechanism of both steps involved in the synthesis of
isoxazole (5). Why is a base (triethyl amine) required in the first step of the pathway?
What is the byproduct (4) of this step?
NH2
CI
-NH
H3C-
Ph
H3C-
-CH3
1
4
Robinson
H3PO4
Gabriel
-N-
H3C-
CH3
H20
5
4. Using curved arrows, draw the mechanism of both steps involved in the synthetic
pathway to thiazole (3).
.CI
S
Heat
Heat
-N
-R1
R-
-R1
R1
H2N
- HCI
ò HN
S.
1
3
4
If thiourea (5) was used in the Hantzsch synthesis instead of thioamide (2), what would
be the structure of the resulting thiazole (6)?
.CI
Нeat
-N-
-NH2
H2N
R1
- HCI
1
6
Transcribed Image Text:3. Using curved arrows, draw the mechanism of both steps involved in the synthesis of isoxazole (5). Why is a base (triethyl amine) required in the first step of the pathway? What is the byproduct (4) of this step? NH2 CI -NH H3C- Ph H3C- -CH3 1 4 Robinson H3PO4 Gabriel -N- H3C- CH3 H20 5 4. Using curved arrows, draw the mechanism of both steps involved in the synthetic pathway to thiazole (3). .CI S Heat Heat -N -R1 R- -R1 R1 H2N - HCI ò HN S. 1 3 4 If thiourea (5) was used in the Hantzsch synthesis instead of thioamide (2), what would be the structure of the resulting thiazole (6)? .CI Нeat -N- -NH2 H2N R1 - HCI 1 6
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