3. Below is toxicity dose-response curve for chemicals (a) and (b). What do the shapes of the two curves show in terms of differences and/or similarities between the toxicity characteristics of the two chemicals (a) and (b)? Which chemical is more toxic? -SE (a) Dose Response
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- 2. A 70-kg male subject was given 150 mg of a drug by IV injection. Blood samples were removed and assayed for intact drug. Calculate the slopes and intercepts of the three phases of the plasma level-time plot from the results tabulated below. Give the equation for the curve. Download (.pdf)|Print Time (hours) 0.17 0.33 0.50 0.67 1.00 1.50 2.00 C(μg/mL) 36.2 34.0 27.0 23.0 20.8 17.8 16.5 Time (hours) 3.0 4.0 6.0 7.0 18.0 23.0 C(ug/mL) 13.9 12.0 8.7 7.7 3.2 2.430Granisetron HCl is indicated for the prevention of nausea and vomiting associated with chemotherapy and radiotherapy. Your 90 kg has been prescribed granisetron HCl at the dose recommended on the drug label below. Determine what volume of this medication you will administer at each dose. Indicate the quantity and unit of measure where specified. Quantity: Unit:
- 7. The pediatrician has ordered 5 mg/kg of theophylline anhydrous for a child weighing 51 pounds. How many tablets would be administered to this child? theophylline, anhydrous 100 Tablets 400 mg* UNICONTIN Controlled-Release System Rx only 100 Tablets 1 NDC 67781-251-01 PB Pharmaceuticals Store at 25°C (77°F) excursions permitted between 15-30°C (59-86°F) Usual Dosage: Read accompanying prescribing literature. Dispense in tight, light-resistant container. 3 67781-251-01 L00988 300946-0A8. A service user with panic disorder has been prescribed 32mg cipramil PO. Oral drops in stock are labelled 40mg/mL. How many mL do you administer?18.
- Calculate the following dosage: A doctor's prescription for pepcid is 15.5 mg per kg of body weight per dose. For an adult who weighs 135 lbs, calculate the number of grams to be given in a dose.2. Order: Amoxicillin 100 mg po q6 hr. Child weighs 15 lbs. Safe range is 25-30 mg/kg/24 hr. a. What is the safe 24-hr range? b. Is the ordered dose safe for a 24-hr period? c. How many mg/day is the patient receiving?Given the following data, what is the LD50 for the following toxin?
- 3. The health care provider has prescribed medroxyprogesterone 600mg intramuscularly (IM) to a patient. The pharmacy provides a vial of medroxyprogesterone 400m(g)/(m)L. Using the ratio and proportion method, calculate the volume of medication (in mL) that the nurse would administer.Name the four major classes of pesticides. What are the advantages and disadvantages of each type? CLASS OF PESTICIDE ADVANTAGE DISADVANTAGE Describe the similarities and differences between ionizing and nonionizing radiation. FORM OF RADIATION SIMILARITIES DIFFERENCES Ionizing Non-ionizing Define the term stochastic. How do the stochastic effects of ionizing radiation differ from the nonstochastic effects Match the term and its definition. ANSWER a. Becquerel A. SI unit measure of amount of radioactivity present in a material b. Coulomb/kg B. SI unit measure of amount of exposure to radioactivity c. Curie C. SI unit measure of absorbed dose of radiation d. Gray D. SI unit measure of radiation dose related to biological effect e. Rad E. Common unit measure of amount of radioactivity present in a material f. Rem…4) A 45-year old woman weighing 68 kg is admitted to hospital after a drug overdose. A toxic plasma concentration of 264 mg/mL is recorded on admission. After 35 hours, a plasma concentration of 8.25mg/ml is recorded. Given this information, calculate the half life for this drug.(Assume the distribution is complete and that the elimination is described by a first-order process.)unit- hours