29. Which of the following dose-response relationships is shown by human exposure to lead (which shares the same dose- response pattern exhibited by the heavy metal plutonium)? A. lead exhibits no threshold effects, since it causes toxicity even at the lowest doses B. lead exhibits a wide therapeutic index, with an LD-50 which is far below its TD-50 C. lead exhibits threshold effects, since it causes no toxicity at the lowest doses D. lead has an ED-50 (effective dose) which is higher than its TD-50 (toxic dose) E. lead has a TD-50 (toxic dose) which is higher than its LD-50 (lethal dose)
29. Which of the following dose-response relationships is shown by human exposure to lead (which shares the same dose- response pattern exhibited by the heavy metal plutonium)? A. lead exhibits no threshold effects, since it causes toxicity even at the lowest doses B. lead exhibits a wide therapeutic index, with an LD-50 which is far below its TD-50 C. lead exhibits threshold effects, since it causes no toxicity at the lowest doses D. lead has an ED-50 (effective dose) which is higher than its TD-50 (toxic dose) E. lead has a TD-50 (toxic dose) which is higher than its LD-50 (lethal dose)
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter27: Drugs And Older Adults
Section: Chapter Questions
Problem 9CRQ
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![29. Which of the following dose-response relationships is shown
by human exposure to lead (which shares the same dose-
response pattern exhibited by the heavy metal plutonium)?
A. lead exhibits no threshold effects, since it causes toxicity
even at the lowest doses
B. lead exhibits a wide therapeutic index, with an LD-50 which
is far below its TD-50
C. lead exhibits threshold effects, since it causes no toxicity at
the lowest doses
D. lead has an ED-50 (effective dose) which is higher than its
TD-50 (toxic dose)
E. lead has a TD-50 (toxic dose) which is higher than its LD-50
(lethal dose)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ffca7a4ff-3dea-47ac-b84c-2ea073698ca0%2F6873d10c-4173-4bfe-8667-9b04301a6f98%2Fmfqrp5_processed.jpeg&w=3840&q=75)
Transcribed Image Text:29. Which of the following dose-response relationships is shown
by human exposure to lead (which shares the same dose-
response pattern exhibited by the heavy metal plutonium)?
A. lead exhibits no threshold effects, since it causes toxicity
even at the lowest doses
B. lead exhibits a wide therapeutic index, with an LD-50 which
is far below its TD-50
C. lead exhibits threshold effects, since it causes no toxicity at
the lowest doses
D. lead has an ED-50 (effective dose) which is higher than its
TD-50 (toxic dose)
E. lead has a TD-50 (toxic dose) which is higher than its LD-50
(lethal dose)
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