3) A locus controlling stripe intensity in snakes is known to possess two alleles that are codominant (both alleles are expressed in heterozygotes, and in this case, heterozygotes have a phenotype that is intermediate). This locus is also known to be X linked, with males being the heterogametic sex. A researcher wanted to determine if a population was randomly mating using stripe intensity. She enumerated phenotypes among 200 individuals in the population and obtained the following results. Phenotype # males # females Strong Stripe Intensity 40 16 Intermediate Stripe Intensity 0 48 Weak Stripe Intensity 60 36 Totals 100 100 200 A) Use a X* goodness of fit test to determine if genotype frequencies conform to those expected if the population is randomly mating, given that we know the locus is X linked. (Hints: think carefully about the number of classes and expected number of individuals within each class, and in this case, we lose 1 degree of freedom for using observed numbers of males, and another for using observed numbers of females in addition to those normally lost). Use the table of X critical values provided in the lecture notes. B) Perform a second goodness of fit test, but assume that the locus is NOT X linked C) What is one piece of evidence that can be used to determine if a locus is X linked?

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3) A locus controlling stripe intensity in snakes is known to possess two alleles that
are codominant (both alleles are expressed in heterozygotes, and in this case,
heterozygotes have a phenotype that is intermediate). This locus is also known to be
X linked, with males being the heterogametic sex. A researcher wanted to determine
if a population was randomly mating using stripe intensity. She enumerated
phenotypes among 200 individuals in the population and obtained the following
results.
Phenotype
# males
# females
Strong Stripe
Intensity
40
16
Intermediate
Stripe
Intensity
0
48
Weak Stripe
Intensity
60
36
Totals
100
100
200
A) Use a X goodness of fit test to determine if genotype frequencies conform to those
expected if the population is randomly mating, given that we know the locus is X
linked. (Hints: think carefully about the number of classes and expected number of
individuals within each class, and in this case, we lose 1 degree of freedom for using
observed numbers of males, and another for using observed numbers of females in
addition to those normally lost). Use the table of X critical values provided in the
lecture notes.
B) Perform a second goodness of fit test, but assume that the locus is NOT X linked
C) What is one piece of evidence that can be used to determine if a locus is X linked?
Transcribed Image Text:3) A locus controlling stripe intensity in snakes is known to possess two alleles that are codominant (both alleles are expressed in heterozygotes, and in this case, heterozygotes have a phenotype that is intermediate). This locus is also known to be X linked, with males being the heterogametic sex. A researcher wanted to determine if a population was randomly mating using stripe intensity. She enumerated phenotypes among 200 individuals in the population and obtained the following results. Phenotype # males # females Strong Stripe Intensity 40 16 Intermediate Stripe Intensity 0 48 Weak Stripe Intensity 60 36 Totals 100 100 200 A) Use a X goodness of fit test to determine if genotype frequencies conform to those expected if the population is randomly mating, given that we know the locus is X linked. (Hints: think carefully about the number of classes and expected number of individuals within each class, and in this case, we lose 1 degree of freedom for using observed numbers of males, and another for using observed numbers of females in addition to those normally lost). Use the table of X critical values provided in the lecture notes. B) Perform a second goodness of fit test, but assume that the locus is NOT X linked C) What is one piece of evidence that can be used to determine if a locus is X linked?
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