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2e. What is the probability that Isabella's future son would be affected by ichthyosis? Explain.

2e. What is the probability that Isabella's future son would be affected by ichthyosis? Explain.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2c. Provide genotypes for the following individuals based on the pedigree. Use a "?" if an allele cannot be determined from the information given. Do not assume partners are unaffected so use "?" when an allele cannot be determined. Dylan's partner: David's father: David's mother: Sofia's mother: Sofia: Diego: Isabella: Camila: 2d. What is the probability that Isabella's future daughter would be affected by ichthyosis if her partner is unaffected? Explain. 2e. What is the probability that Isabella's future son would be affected by ichthyosis? Explain.'
Transcribed Image Text:2c. Provide genotypes for the following individuals based on the pedigree. Use a "?" if an allele cannot be determined from the information given. Do not assume partners are unaffected so use "?" when an allele cannot be determined. Dylan's partner: David's father: David's mother: Sofia's mother: Sofia: Diego: Isabella: Camila: 2d. What is the probability that Isabella's future daughter would be affected by ichthyosis if her partner is unaffected? Explain. 2e. What is the probability that Isabella's future son would be affected by ichthyosis? Explain.'
2. David has ichthyosis, which is an X-linked recessive skin condition that is caused by a deficiency of the enzyme steroid sulfatase. The deficiency disrupts cholesterol sulfate metabolism; cholesterol sulfate plays a role in maintaining skin integrity. The normal shedding of dead skin cells is inhibited, and skin cells build up and clump into scales. The application of skin softening creams, lotions and other topical treatments lessens the severity of symptoms. David's partner Sofia is the daughter of David's maternal aunt. David and Sofia have two sons, Diego and Daniel, and one daughter, Isabella, all of whom have ichthyosis. They also have two unaffected daughters, Mia and Camila. David's maternal grandfather, Dylan, is also affected by ichthyosis. 2a. Based on the family described above, draw a pedigree indicating individual names, biological sex (square or circle), affected/unaffected (shaded/unshaded), and relationship connections. If the individual in the pedigree has not been specifically mentioned to have ichthyosis, assume they do not have the condition. 2b. Describe how the pedigree you drew is consistent with X-linked recessive inheritance? Explain your answer by providing at least TWO pieces of evidence taken from the pedigree.
Transcribed Image Text:2. David has ichthyosis, which is an X-linked recessive skin condition that is caused by a deficiency of the enzyme steroid sulfatase. The deficiency disrupts cholesterol sulfate metabolism; cholesterol sulfate plays a role in maintaining skin integrity. The normal shedding of dead skin cells is inhibited, and skin cells build up and clump into scales. The application of skin softening creams, lotions and other topical treatments lessens the severity of symptoms. David's partner Sofia is the daughter of David's maternal aunt. David and Sofia have two sons, Diego and Daniel, and one daughter, Isabella, all of whom have ichthyosis. They also have two unaffected daughters, Mia and Camila. David's maternal grandfather, Dylan, is also affected by ichthyosis. 2a. Based on the family described above, draw a pedigree indicating individual names, biological sex (square or circle), affected/unaffected (shaded/unshaded), and relationship connections. If the individual in the pedigree has not been specifically mentioned to have ichthyosis, assume they do not have the condition. 2b. Describe how the pedigree you drew is consistent with X-linked recessive inheritance? Explain your answer by providing at least TWO pieces of evidence taken from the pedigree.
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