27. Glycolysis and the citric acid cycle comprise two different sets of oxidation reactions. The reaction sequence for glycolysis is linear, whereas the reaction sequence for the citric acid cycle forms a circle. How does this difference in the arrangement of reactions influence the rate of these processes when an excess amount of a single intermediate is added?

27. Glycolysis and the citric acid cycle comprise two different sets of oxidation reactions. The reaction sequence for glycolysis is linear, whereas the reaction sequence for the citric acid cycle forms a circle. How does this difference in the arrangement of reactions influence the rate of these processes when an excess amount of a single intermediate is added?

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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What if the phosphate group for the glycolysis reaction with enzyme glyceraldehyde 3-phosphate dehydrogenase was from ATP instead of Pi? What would the complete, balanced, net rxn of glycoslysisequation be and how does this impact the overall glycolysis rxn?
The functioning of a particular pathway often depends not only on control enzymes in that pathway but alsoon control enzymes of other pathways. What happens in the following pathways under the indicated conditions? Suggest what otherpathway or pathways might be influenced.(a) High ATP or NADH concentration and the citric acid cycle.(b) High ATP concentration and glycolysis.(c) High NADPH concentration and the pentose phosphate pathway.(d) High fructose-2,6-bisphosphate concentration and gluconeo genesis.
For each step of the citric acid cycle, name the enzyme responsible for the chemical transformation that occurs and classify the enzyme type: Step 1. Step 2. Step 3. Step 4. Step 5. Step 6. Step 7. Step 8. i. oxidoreductase (oxidases, reductases, dehydrogenases) ii. transferase (transaminases, kinses) iii. hydrolase (lipases, proteases, nucleases, carbohydrases, phosphateses) iv. lyase (dehydratase, decarboxylase, deaminase, hydratase) v. isomerase (racemases, mutases) vi. ligase (synthetases, carboxylaces) Enzyme Name Enzyme Type
Some cofactors that participate in the reactions of the citric acid cycle are indicated by letters. Identify the position of positions of NADH in the cycle by selecting the appropriate letter or letters designating its position(s) in the cycle diagram. COA CH, HO--Co, CH čo, 8 CO но-сн CH HC -Co, CO HO-CH LA Citric acid cycle H,0 co, -B COA | 4 Co, čo D.
Why is it reasonable for excess NADH to negatively regulate the citric acid cycle?
a) What carbon-containing molecule exits the citric acid cycle? Why doesn’t your body capture the carbon-containing molecule you identified in part (a) and use that molecule to build new sugars and fats? Explain your answer. You have just created a new enzyme that will make the citric acid cycle more efficient! Instead of the citric acid cycle taking 8 steps, all of the bonds between the carbon atoms will be broken in only one step! Is this a good idea? Explain your answer.
trace the position of the elctron as this glucose molecule proceeds through glycolsis and two turns of the citric acid cycle
● 1.) Draw out the pathway for the biosynthesis of the following glycerophospholipid starting with choline, glycerol and the component fatty acids as it occurs in the liver tissue. Show the structures of all reactants and products, as well as the names of the enzymes. You do not need to draw the structures of ATP, NAD+, CoA, etc., but do show them as reactants or products in the appropriate places. You do not need to show the mechanisms of the enzymes. What is the name of the phospholipid? Us jure O • DISM 91 3.C6H3 UG OSEMSA QE F CH₂ CABJAD C-H H H₂C-O-P-0- ACELOj Pro ! H₂ C 212 32 CH3 f H3C -N-CH3
Acetyi CoA Oxaloncetate CoA NADH Citrate NAD Isocitrate Malate Funiarate NAD co NADH FADH, FAD a- Ketoghutarate Succinate co, NAD+ ATP Succinyl CuA NADH ADP - P For each molecule of glucose (C6H12O6) oxidized by cellular respiration, how many moles of CO2 are released in the citric acid cycle? (see the figure above) а. 2 b. 4 с. 6 d. 0 е. 3
Draw OUT THE arrow pushing reaction mechanism for the following steps of glycolysis: SHOW/IDENTIFY the arrow pushing mechanism in at least 2 steps. CH,OPO CH,OH hexokinase 2+ H H H H H H ОН + ATP OH H ADP + H+ H ОН + НО HO OH H ОН H ОН Glucose-6-phosphate (G6P) Glucose
[AktivGrid] Draw the product of the reaction of isocitrate catalyzed by isocitrate dehydrogenase in the TCA (citric acid) cycle. Provide the structure in the protonation state found in physiological conditions. 9 H-C-OH 800- -H CH₂ ° Coo of NAD+ dehydrogen isocitrate ase NADH, H*, Drawing CO2
9. The equation below depicts the first step of the citric acid cycle. H0 CoA-SH CH-C + 0=C-CO0 HO C-COO citrate s-COA ČH2-COO synthase ČH2 -CO0 Citrate Acetyl-CoA Oxaloacetate AG" = -32.2 kJ/mol a) Explain the chemical conversions that take place during this step. b) Why is this reaction energetically favorable? Explain.