Congenital adrenal hyperplasia is a lifethreatening condition that results from a deficiency in the P450 enzyme steroid 21- hydroxylase. This enzyme catalyzes the first step in the conversion of progesterone into cortisol and aldosterone (Figures 26.28 and 26.29). A characteristic of congenital adrenal hyperplasia is an increase in sex hormone production. Explain why this is the case. 21H3CHOH,CCHsCH3CH3OH1711CH3ÇH3CH3HOPregnenoloneProgesteroneCortisol2121HOH,CHOH,CH3HQHQOH1711ÇH311ÇH318FIGURE 26.28 Pathways for the formation ofprogesterone, cortisol, and aldosterone.CorticosteroneAldosterone ProgesteroneH3CÇH3ÇHsCH3OHOH17CH3CH317«-HydroxyprogesteroneAndrostenedioneTestosteroneCH3CH3HOFIGURE 26.29 Pathways for the formationof androgens and estrogens.HOEstroneEstradiol

Sex hormones are primarily steroid hormones. The sex hormones can be divided into male sex hormones…

Answered: 21 H3C HOH,C CHs CH3 CH3 OH 17 11 CH3…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Congenital adrenal hyperplasia is a lifethreatening condition that results from a deficiency in the P450 enzyme steroid 21- hydroxylase. This enzyme catalyzes the first step in the conversion of progesterone into cortisol and aldosterone (Figures 26.28 and 26.29). A characteristic of congenital adrenal hyperplasia is an increase in sex hormone production. Explain why this is the case.

21
H3C
HOH,C
CHs
CH3
CH3
OH
17
11
CH3
ÇH3
CH3
HO
Pregnenolone
Progesterone
Cortisol
21
21
HOH,C
HOH,
CH3
HQ
HQ
OH
17
11
ÇH3
11
ÇH3
18
FIGURE 26.28 Pathways for the formation of
progesterone, cortisol, and aldosterone.
Corticosterone
Aldosterone

Progesterone
H3C
ÇH3
ÇHs
CH3
OH
OH
17
CH3
CH3
17«-Hydroxyprogesterone
Androstenedione
Testosterone
CH3
CH3
HO
FIGURE 26.29 Pathways for the formation
of androgens and estrogens.
HO
Estrone
Estradiol

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