20 tablets containing the dibasic drug ethambutol hydrochloride (MW 277.2 g/mol) were powdered. 0.3354 g of tablet powder was dissolved in 10 mL of 2 M sodium hydroxide and was extracted with 5 x 25 mL quantities of chloroform. The combined extracts were evaporated and the residue was dissolved in 100 mL of anhydrous acetic acid. Non-aqueous titration was carried out using 1-naphtholbenzein solution as indicator and 0.1014 M acetous perchloric acid. Volume of acetous perchloric acid required = 14.2 mL, weight of 20 tablets = 3.367 g, state content of ethambutol hydrochloride per tablet = 100 mg. Calculate the % of stated content in the tablets.
20 tablets containing the dibasic drug ethambutol hydrochloride (MW 277.2 g/mol) were powdered. 0.3354 g of tablet powder was dissolved in 10 mL of 2 M sodium hydroxide and was extracted with 5 x 25 mL quantities of chloroform. The combined extracts were evaporated and the residue was dissolved in 100 mL of anhydrous acetic acid. Non-aqueous titration was carried out using 1-naphtholbenzein solution as indicator and 0.1014 M acetous perchloric acid. Volume of acetous perchloric acid required = 14.2 mL, weight of 20 tablets = 3.367 g, state content of ethambutol hydrochloride per tablet = 100 mg. Calculate the % of stated content in the tablets.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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20 tablets containing the dibasic drug ethambutol
hydrochloride (MW 277.2 g/mol) were powdered. 0.3354 g of
tablet powder was dissolved in 10 mL of 2 M sodium hydroxide
and was extracted with 5 x 25 mL quantities of chloroform.
The combined extracts were evaporated and the residue was
dissolved in 100 mL of anhydrous acetic acid. Non-aqueous
titration was carried out using 1-naphtholbenzein solution as indicator and 0.1014 M acetous perchloric acid.
Volume of acetous perchloric acid required = 14.2 mL, weight of 20 tablets = 3.367 g, state
content of ethambutol hydrochloride per tablet = 100 mg.
Calculate the % of stated content in the tablets.
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