OH-%OHOHH₂HOHN,OHFigure 1 Structure of TTXNa-OH₂on ChannelMembraneJon ChamelTetrodotoxinFigure 1 Binding of TTX to Sodium channelwww.www.www.wwwwww.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order thatincludes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by bindingto the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signaltransmission. Propose a computational research project in which you would use TTX as a startingmaterial to design a painkiller (an analgesic drug).Note the following:(50 Marks)You must clearly mention the computational methods/techniques and their significance in thisresearch.Sodium channel Nv1.7 is a transmembrane protein.• TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. Thisis schematically represented in Figure 2.Strong Painkillers partially/ irreversibly block Na channels.

Binding of TTX to Sodium ChannelThe image shows a diagram of the structure of tetrodotoxin (TTX) and…

Answered: OH -% OH OH H₂ HO HN, OH Figure 1…

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

Section: Chapter Questions

Problem 57QRT

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You have a 11.5 mg sample of blood that contains various proteins. Hemoglobin is the only protein in the sample containing Fe. Hemoglobin contains 3.83% by mass of a compound called heme (C₃₄H₃₂FeN₄O₄, MW = 616.49 g/mol). You find that your 11.5 mg blood sample contains 30.5 micrograms of Fe. What is the mass percent of hemoglobin in your protein sample?
to Johnston Commun X Rh Blackboard Collaborate Ultra - x > General Psychology-Fall 2021 A ALEKS - Griffin Barden - Learn + A www-awa.aleks.com/alekscgi/x/Isl.exe/1o_u-IgNslkr7j8P3jH-IJczzdcvSCzsqTCIDqNGV3bKqhMfPmUcQ4ENkmiXn9QCwgeDPDkQ06yszYWESPcekwLO-Qg619rekU7404HgFAGbEZa Dr080?1 oBw7QYjlbavbSPXtx-YCjsh_7mMmrq#item O THERMOCHEMISTRY Griffin Calculating a molar heat of reaction from formation enthalpies Using the table of standard formation enthalpies that you'll find under the ALEKS Data tab, calculate the reaction enthalpy of this reaction under standard conditions: 2C,H;(g)+70,(9)→4 CO,(g)+6H,O() Round your answer to the nearest kJ.
You have a 11.5 mg sample of blood that contains various proteins. Hemoglobin is the only protein in the sample containing Fe. Hemoglobin contains 3.83% by mass of a compound called heme (C₃₄H₃₂FeN₄O₄, MW = 616.49 g/mol). You find that your 11.5 mg blood sample contains 34.9 micrograms of Fe. What is the mass percent of hemoglobin in your protein sample? -don't prematureley round
1. Calculate the Coulombic (ionic) interaction energy between atoms for the C=O ∙∙∙H-N hydrogen bond in a peptide at a distance of 1.5Å in units of kJ/mol. Assume that the partial charge on O is −0.434, the partial charge on H is +0.417 and the permittivity of the protein environment is 6. coulimbic interaction energy= 27.95 kJ/mol 2. The dipole moment of an individual peptide group is approximately 3.46 D. Assuming that the dipoles line up linearly estimate the energy of interaction (in kJ.mol) of the hydrogen bond in Q1 using a dipole-dipole model. *******please answer #2**********
1) SOCI₂, Et3N OH 2) + AICI 3
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A direct enzyme-linked immunosorbent assay (ELISA) test on a patient's sample is shown below. Development of a strong (dark) color reaction would indicate: 1 Antibody is adsorbed to well. 2 Patient sample is added; complementary antigen binds to antibody. 3 Enzyme-linked antibody specific 4 Enzyme's substrate () is added, for test antigen is added and binds and reaction produces a product that causes a visible color change (O). to antigen, forming sandwich. A low concentration of a specific antigen in the patient's sample O A high concentration of a specific enzyme in the patient's sample The patient's antibody is specific for the enzyme's substrate O A high concentration of a specific antigen in the patient's sample A high concentration of a specific antibody (against the test antigen) in the patient's sample
You are trying to come up with a drug to inhibit the activity of an enzyme thought to have a role in liver disease. In the laboratory the enzyme was shown to have a Km of 1.0 x 10-6 M and Vmax of 0.1 micromoles/min.mg measured at room temperature. You developed an uncompetitive inhibitor. In the presence of 5.0 x 10-5 M inhibitor, the apparent Vmax was determined to be 0.02 micromoles/min.mg. What is the Ki of the inhibitor?
Solve the problem in image ASAP, thank u
You work in a research organization that is looking for markers of various diseases that can be used as a diagnostic for the disease. It has been reported in the past that high levels of Cu are found in the sweat of people with cystic fibrosis. One of the research projects is focused on looking for high levels of Cu in samples that can be obtained non-invasively such as saliva, sweat, hair, nails, etc. The lab will analyze large samples for Cu. What instrument would you recommend purchasing to support this work, Atomic absorption spectrophotometer or an inductively coupled plasma atomic spectrophotometer? Explain the basis for your decision.
19
6. A 190 lb worker in a factory received an exposure to AB which has a molecular weight (MW) of 278 g/mole. AB is completely metabolized in the body to A (MW 194) and B. A is completely excreted in the urine and B is further metabolized to five different compounds. A 24-hr total urine sample was 2060 ml, Analysis showed the concentration of A in the urine was 1.28 ng/mL What was the absorbed dose of AB in ug/kg body wt?

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