OH-%OHOHH₂HOHN,OHFigure 1 Structure of TTXNa-OH₂on ChannelMembraneJon ChamelTetrodotoxinFigure 1 Binding of TTX to Sodium channelwww.www.www.wwwwww.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order thatincludes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by bindingto the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signaltransmission. Propose a computational research project in which you would use TTX as a startingmaterial to design a painkiller (an analgesic drug).Note the following:(50 Marks)You must clearly mention the computational methods/techniques and their significance in thisresearch.Sodium channel Nv1.7 is a transmembrane protein.• TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. Thisis schematically represented in Figure 2.Strong Painkillers partially/ irreversibly block Na channels.

Binding of TTX to Sodium ChannelThe image shows a diagram of the structure of tetrodotoxin (TTX) and…

Answered: OH -% OH OH H₂ HO HN, OH Figure 1…

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

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The activity of an enzyme requires a glutamic acid to display its –COOH functional group in the protonated state. Suppose the pKa of the -COOH group is 4.07. What fraction of the enzymes will be active at pH = 4.07? 25% O 75% O 50% 100% 0% Submit Previous Answers Completed Part C At what pH will the enzyme show 80% of maximal activity? Express your answer using two decimal places. ν ΑΣφ pH = Submit Request Answer
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to Johnston Commun X Rh Blackboard Collaborate Ultra - x > General Psychology-Fall 2021 A ALEKS - Griffin Barden - Learn + A www-awa.aleks.com/alekscgi/x/Isl.exe/1o_u-IgNslkr7j8P3jH-IJczzdcvSCzsqTCIDqNGV3bKqhMfPmUcQ4ENkmiXn9QCwgeDPDkQ06yszYWESPcekwLO-Qg619rekU7404HgFAGbEZa Dr080?1 oBw7QYjlbavbSPXtx-YCjsh_7mMmrq#item O THERMOCHEMISTRY Griffin Calculating a molar heat of reaction from formation enthalpies Using the table of standard formation enthalpies that you'll find under the ALEKS Data tab, calculate the reaction enthalpy of this reaction under standard conditions: 2C,H;(g)+70,(9)→4 CO,(g)+6H,O() Round your answer to the nearest kJ.
One common way to determine phosphorus in urine is to treat the sample, after removing the protein, with Mo (VI) and then reducing the resulting 12-molybdophosphate complex with ascorbic acid to give an intense blue colored species called molybdenum blue. The absorbance of molybdenum blue can be measured at 650nm. A 24-hour urine sample was collected and the patient produced 1122mL in 24 hours. A 1.00mL aliquot of the sample was treated with Mo(VI) and ascorbic acid and diluted to a volume of 50.00mL. A calibration curve was prepared by treating 1.00mL aliquots of phosphate standard solutions in the same manner as the urine sample. The absorbances of the standards and the urine sample were obtained at 650nm and the following results obtained: Solution Absorbance at 650nm: 1ppm P0.2302ppm P0.4363ppm P0.6384ppm P0.848Urine sample 0.518 How many grams of phosphorus were eliminated per day by the patient?
C LOCH3 250 °C HBr }) m-CPBA MgBr
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3. In patients with early stage lung cancer, stereotactic body radiation therapy (SBRT) has greatly improved survival in patients unable to undergo surgery. In tumors 100 Gy 10 BED have demonstrated significantly improved survival, when compared with doses <100 Gy 10. What is the BED of the following protocol? Would you suggest increasing the dose, or does it appear adequate, assuming the given information? What would you expect as the most likely side effect of therapy for this patient? 3 fractions of 15 Gy delivered every other day.
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Hello, I would like help with problem 41 in the image attached.

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