OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter13: The Chemistry Of Solutes And Solutions
Section: Chapter Questions
Problem 57QRT
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OH
-%
OH
OH
H₂
HO
HN,
OH
Figure 1 Structure of TTX
Na-OH₂
on Channel
Membrane
Jon Chamel
Tetrodotoxin
Figure 1 Binding of TTX to Sodium channel
www.www.
www.www
www.www.
Transcribed Image Text:OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www.
2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that
includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding
to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal
transmission. Propose a computational research project in which you would use TTX as a starting
material to design a painkiller (an analgesic drug).
Note the following:
(50 Marks)
You must clearly mention the computational methods/techniques and their significance in this
research.
Sodium channel Nv1.7 is a transmembrane protein.
• TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This
is schematically represented in Figure 2.
Strong Painkillers partially/ irreversibly block Na channels.
Transcribed Image Text:2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.
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