2. Nerve agents are one example of toxic enzyme inhibitors. These chemical weapons were first developed in Germany during WII. Sarin is a nerve agent that has been used in terrorist weapons. This substance binds strongly with the active site on cholinesterase, the enzyme responsible for breaking down the neurotransmitter acetylcholine. Acetylcholine is an excitatory neurotransmitter. Disabling of this enzyme results in a progressive loss of body functions, eventually leading to death if the affected person is not treated. Even a pinhead-sized drop of sarin can kill an adult human. (a) Of what form of enzyme inhibition is sarin an example? Justify your reasoning. (b) Propose detail how sarin would affect proper nerve cell functioning. (c) Would you consider sarin a drug that causes an inhibitory or excitatory nerve response? Defend your response.

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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2. Nerve agents are one example of toxic enzyme inhibitors. These chemical
weapons were first developed in Germany during WII. Sarin is a nerve agent that
has been used in terrorist weapons. This substance binds strongly with the active
site on cholinesterase, the enzyme responsible for breaking down the
neurotransmitter acetylcholine. Acetylcholine is an excitatory neurotransmitter.
Disabling of this enzyme results in a progressive loss of body functions, eventually
leading to death if the affected person is not treated. Even a pinhead-sized drop of
sarin can kill an adult human.
(a) Of what form of enzyme inhibition is sarin an example? Justify your reasoning.
(b) Propose detail how sarin would affect proper nerve cell functioning.
(c) Would you consider sarin a drug that causes an inhibitory or excitatory nerve
response? Defend your response.
Transcribed Image Text:2. Nerve agents are one example of toxic enzyme inhibitors. These chemical weapons were first developed in Germany during WII. Sarin is a nerve agent that has been used in terrorist weapons. This substance binds strongly with the active site on cholinesterase, the enzyme responsible for breaking down the neurotransmitter acetylcholine. Acetylcholine is an excitatory neurotransmitter. Disabling of this enzyme results in a progressive loss of body functions, eventually leading to death if the affected person is not treated. Even a pinhead-sized drop of sarin can kill an adult human. (a) Of what form of enzyme inhibition is sarin an example? Justify your reasoning. (b) Propose detail how sarin would affect proper nerve cell functioning. (c) Would you consider sarin a drug that causes an inhibitory or excitatory nerve response? Defend your response.
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Sarin is a man made chemical or bio weapon that can severely affect the nerves of the brain and can be fatal.

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