2. Ingestion of toxic mushrooms is a common source of accidental poisoning. Alpha and beta amanitins are toxins found in some poisonous mushrooms. When individuals are taken to the hospital for mushroom poisoning, plasma and urine amanitin levels are often measured to assess the degree of intoxication. Using the following amanitin measurements, estimate the renal clearance of these toxins in each patient. (a) Patient 1: Urine collected from 20-28 hr contained 550 µg of alpha amanitin, while a plasma sample drawn at 24 hr had an alpha amanitin concentration of 40.2 µg/L. (b) Patient 2: Plasma beta amatinin levels measured at 9 hr and 18 hr were 162 µg/L and 119 µg/L. Urine collected from 9 hr to 18 hr contained 798 µg beta amatinin.

2. Ingestion of toxic mushrooms is a common source of accidental poisoning. Alpha and beta amanitins are toxins found in some poisonous mushrooms. When individuals are taken to the hospital for mushroom poisoning, plasma and urine amanitin levels are often measured to assess the degree of intoxication. Using the following amanitin measurements, estimate the renal clearance of these toxins in each patient. (a) Patient 1: Urine collected from 20-28 hr contained 550 µg of alpha amanitin, while a plasma sample drawn at 24 hr had an alpha amanitin concentration of 40.2 µg/L. (b) Patient 2: Plasma beta amatinin levels measured at 9 hr and 18 hr were 162 µg/L and 119 µg/L. Urine collected from 9 hr to 18 hr contained 798 µg beta amatinin.