2-methoxypyrrole is brominated exhaustively by treatment with Br2, while 2- methoxypyridine is selectively brominated at the 5-position. Explain the differences in reactivity, and the regioselectivity of the pyridine bromination, using resonance structures as part of your explanation.
Organomagnesium compounds
The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.
Hydrolysis Grignard Reactions and Reduction
Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.
2-methoxypyrrole is brominated exhaustively by treatment with Br2, while 2-
methoxypyridine is selectively brominated at the 5-position. Explain the
differences in reactivity, and the regioselectivity of the pyridine bromination,
using resonance structures as part of your explanation.
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