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- Histamine, whose release in the body triggers nasal secretions and constricted airways, has three nitrogen atoms. List them in order of increasing basicity and explain your ordering.15.44 Rank the following compounds in order of increasing acidity. A B CRank the compounds in each group in order of increasing basicity. NH2 NH2 NH2 a. NH3 -NH2 -NH2 c. O,N CH3 b. d. C3H;NH, (C6H5)2NH -NH2 N' H H
- Amphetamine is a powerful stimulant of the central nervous system. (a) Which proton in amphetamine is most acidic? (b) What products are formed when amphetamine is treated with NaH? (c) What products are formed when amphetamine is treatedRank the compounds in each group in order of increasing basicity. NH2 NH2 NH2 a. NH3 -NH2 -NH2 ON CH d. CgH;NH2 (CeHs)2NH -NH2 b. H.Rank the compounds in each group in order of increasing basicity. „NH2 NH2 a. NH3 -NH2 -NH2 С. O,N CH; b. d. CgH;NH2 (C;H3);NH –NH2 `N'
- Varenicline (trade name Chantix) is a drug used to help smokers quittheir habit. (a) Which N atom in varenicline is most basic? Explain your choice. (b) What product is formed when varenicline is treated with HCl?the aryl compound with higher basicity from the following compounds : Select one: a. H2N b. H2N H2N d. H2N NO2 OCH3 CN CIRank the labeled N atoms in the anticancer drug imatinib (trade nameGleevec) in order of increasing basicity. Imatinib, sold as a salt withmethanesulfonic acid (CH3SO3H), is used for the treatment of chronicmyeloid leukemia as well as certain gastrointestinal tumors.
