19. Chemical damage to DNA can result when alkylating agents react with one of the basepairs of DNA. This disrupts the hydrogen bonding interaction between base pairs.Illustrate the mechanism of reaction for the methylation of guanine with themethyldiazonium ion that forms when N-methyl-N-nitrosourea and acid interact.

Alkylating agents are those agents which bind to certain chemical groups found in nucleic acids.…

Answered: 19. Chemical damage to DNA can result…

19. Chemical damage to DNA can result when alkylating agents react with one of the base pairs of DNA. This disrupts the hydrogen bonding interaction between base pairs.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter8: The Structure, Replication, And Chromosomal Organization Of Dna

Section: Chapter Questions

Problem 7QP: List the pyrimidine bases, the purine bases, and the base-pairing rules for DNA.

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Concept explainers

Nucleotides

It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).

Nucleic Acids

Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.

Question

19. Chemical damage to DNA can result when alkylating agents react with one of the base
pairs of DNA. This disrupts the hydrogen bonding interaction between base pairs.
Illustrate the mechanism of reaction for the methylation of guanine with the
methyldiazonium ion that forms when N-methyl-N-nitrosourea and acid interact.

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