Can u help me to explain to me, please? I stuggled. 15.23) Explain the difference between ketogenesis and ketoacidosis.YOUR ANSWER SHOULD BE SOMETHING LIKE THIS (perhaps a bit less detailed):Acetyl-CoA that is produced in excess of the amount that can be metabolized in the citric acid cycle results in a highconcentration of acetyl-CoA. When this occurs, acetyl-CoA reacts with other acetyl-CoA to produce the threecompounds that are referred to as ketone bodies. This process is referred to as ketogenesis. Ketone bodies are producedas shown in the reactions below. When individuals diet, they begin to metabolize the triglycerides that are stored in fatcells. This leads to ketogenesis.NAD+ОНCH₂CH-CH₂C-0B-hydroxybutyrateiCH₂C-COAacetyl-CoANADH + H++iCH₂C-CoAacetyl-CoAH₂O2 H-COA+H*CH₂C-CH₂C-0acetoacetateketone bodiesCO₂sCH₂-C-CH₂acetoneIn cases of starvation, poorly treated diabetes, and conditionsrelated to alcoholic binge drinking, the cells cannot get glucoseand extremely high rates of fatty acid catabolism results indangerous, and even fatal levels of ketone bodies. ß-hydroxybutyric acid and acetoacetic acid (the acid forms of ß-hydroxybutyrate and acetoacetate, respectively) have significantacid strength. Their production results in a higher concentrationof H3O+, which can overcome the blood's buffering capacity.When this occurs, the blood becomes acidic. When blood pH isless than the normal range (7.35-7.45), the condition is calledacidosis. When acidosis is caused by excess ketone bodies, thecondition is called ketoacidosis.

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15.23) Explain the difference between ketogenesis and ketoacidosis.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Question

Can u help me to explain to me, please? I stuggled.

15.23) Explain the difference between ketogenesis and ketoacidosis.
YOUR ANSWER SHOULD BE SOMETHING LIKE THIS (perhaps a bit less detailed):
Acetyl-CoA that is produced in excess of the amount that can be metabolized in the citric acid cycle results in a high
concentration of acetyl-CoA. When this occurs, acetyl-CoA reacts with other acetyl-CoA to produce the three
compounds that are referred to as ketone bodies. This process is referred to as ketogenesis. Ketone bodies are produced
as shown in the reactions below. When individuals diet, they begin to metabolize the triglycerides that are stored in fat
cells. This leads to ketogenesis.
NAD+
ОН
CH₂CH-CH₂C-0
B-hydroxybutyrate
i
CH₂C-COA
acetyl-CoA
NADH + H+
+
i
CH₂C-CoA
acetyl-CoA
H₂O
2 H-COA+H*
CH₂C-CH₂C-0
acetoacetate
ketone bodies
CO₂
s
CH₂-C-CH₂
acetone
In cases of starvation, poorly treated diabetes, and conditions
related to alcoholic binge drinking, the cells cannot get glucose
and extremely high rates of fatty acid catabolism results in
dangerous, and even fatal levels of ketone bodies. ß-
hydroxybutyric acid and acetoacetic acid (the acid forms of ß-
hydroxybutyrate and acetoacetate, respectively) have significant
acid strength. Their production results in a higher concentration
of H3O+, which can overcome the blood's buffering capacity.
When this occurs, the blood becomes acidic. When blood pH is
less than the normal range (7.35-7.45), the condition is called
acidosis. When acidosis is caused by excess ketone bodies, the
condition is called ketoacidosis.

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