11. A radical cyclization cascade was used in the total synthesis of the natural product, hirsutene. Propose a mechanism for this transformation. Hints: a) Start by using the tin radical (left) to abstract the iodide. b) After both new rings are formed, an H atom can be abstracted from Bu3Sn–H to complete the mechanism. 11. A radical cyclization cascade was used in the total synthesis of the natural product, hirsutene. Propose amechanism for this transformation. Hints: a) Start by using the tin radical (left) to abstract the iodide. b) Afterboth new rings are formed, an H atom can be abstracted from Bu;Sn-H to complete the mechanism.BuzSnHAĪBNBu, Snbenzene80 °C80% yieldhirsutene

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Answered: 11. A radical cyclization cascade was…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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11. A radical cyclization cascade was used in the total synthesis of the natural product, hirsutene. Propose a mechanism for this transformation. Hints: a) Start by using the tin radical (left) to abstract the iodide. b) After both new rings are formed, an H atom can be abstracted from Bu3Sn–H to complete the mechanism.

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