11. A radical cyclization cascade was used in the total synthesis of the natural product, hirsutene. Propose a mechanism for this transformation. Hints: a) Start by using the tin radical (left) to abstract the iodide. b) After both new rings are formed, an H atom can be abstracted from Bu3Sn-H to complete the mechanism. Bu,SnH AİBN BuzSn' benzene 80 °C H 80% yield hirsutene
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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