1. R/S, E/Z, and Chirality(a)Assign the priorities (#1 through #4) for the groups of the stereocenter in each molecule.Based on those assigned priorities, predict the configuration (R or S). Include the priority #directly adjacent to one of the atoms in the corresponding group.(i)(ii)HOH CH3H₂NH

Step 1: Step 2: Step 3: Step 4:

Answered: 1. R/S, E/Z, and Chirality (a) Assign…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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For the following molecules, draw all possible stereoisomers using line-angle formulas with wedge/dash notation. Label the stereocenters as R or S. Indicate which ones are enantiomers and which ones are diastereomers. (Remember: there are 2 stereoisomers possible for a molecule with n chiral centers) (A) (B) (C) (1 chiral center) Br OH (2 chiral centers) CI OH CH3 (3 chiral centers)
7. a) Identify all the chiral/stereogenic centres in the following molecules. Circle the chiral carbon(s). OH CI -Br CI ОН O,N CI Br CI CI A B OH HO, .CI Br HO OH b) For each chiral center, prioritize the groups (1-4) attached to each chiral center(s) Based on your priorities, assign R or S configurations to the chiral center(s). i) Но ii) H2N H ОН но OH iv) OH OH v) H,N- ČH,OH Draw the most stable chair conformation for each of the following cyclohexanes. Now, "flip" the ring and redraw the molecule in the higher energy form. i) chlorocyclohexane ii) cis-1-chloro-2-methylcyclohexane iii) trans-1-methyl-3-propylcyclohexane
3. Assign R or S configuration to the chirality centers of the following molecules; Cl CH3 CH3 а) b) HO C СООН СООН H;C H CH,CH3 H Br ОН CH,CH3 VIl. H ОН e) f) d) Cl H H OCH3 Br H. Br ...|| h) СООН HOCH, H3C CH3
Draw a structural formula of the SR configuration of the compound shown below.
Organic Chemistry, Ch.4, WS #2, Stereochemistry - Review of R&S configuration, Fischer Projections, Enantiomers, Diastereomers, Meso Compounds. 1. Assign R or S configuration to each stereocenter. (a) H₂C H₂C a H- H OH CH₂CH₂ - Br CH, (b) 2. For each Fischer Projection, assign R or S configuration. CH₂ CH₂CH₂ b. H₂N- H COOH + -H CH₂ C-OH (c) HTC OH CH₂OH C. Br- CH₂OH CI CHO CH
2. The following molecule is one enantiomer of methylenedioxymethamphetamine (MDMA). 2a. Circle all of the stereocenters in MDMA 2b. Assign the absolute stereochemistry (R or S) for each stereocenter .CH3 HN H H *CH3
(k) (1) OH SOCI₂ 1) BH 3 THF 2) H₂O2, NaOH Rationalize the stereochemical outcomes for A and B CH3 A ...OH B TSCI pyridine LICI
VIII. Assign R, S configurations to each chirality center in the molecule below. Br CH3 X OH CH3 I I (
None
Consider the structure of the molecule below The absolute configuration (R/S) of the chiral carbon with chlorine is The enantiomer of this structure is (draw it to the right): Draw a constitutional isomer of the molecule (draw it to the right):
8. Two structures of Lipitor (a drug used to lower cholesterol) are shown below. (a) Determine the absolute configuration of each indicated stereocenter. Fill in the correct circle. (b) Determine if the two structures are the same compound or stereoisomers. Fill in the correct circle. (a) НО. Carbon a HO O OH Carbon a: OR OS Carbon b H N Carbon b: R OS of H Carbon c: OR OS OH OH Carbon c F Carbon d: R OS OH Carbon d (b) The two structures are: O the same compound O stereoisomers
In the molecule in the image: i) indicate how many stereogenic centres there are and if the molecule is overall chiral or not ii) assign the appropriate stereodescriptors to the molecules

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