1. Researchers studying the effect of antibiotic treatment for acute sinusitis compared to symptomatic treatments randomly assigned 166 adults diagnosed with acute sinusitis to one of two groups: treatment or control. Study participants received either a 10-day course of amoxicillin (an antibiotic) or a placebo similar in appearance and taste. The placebo consisted of symptomatic treatments such as acetaminophen, nasal decongestants, etc. At the end of the 10-day period, patients were asked if they experienced improvement in symptoms. The distribution of responses is summarized below.³ Group Treatment Control Total Self-reported improvement in symptoms Yes 66 65 131 No 19 10 16 35 Total 85 81 166 (a) What percent of patients in the treatment group experienced improvement in symptoms? (b) What percent experienced improvement in symptoms in the control group? (c) In which group did a higher percentage of patients experience improvement in symptoms? (*) (*

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1.2 Sinusitis and antibiotics, Part I. Researchers studying the effect of antibiotic treatment for acute
sinusitis compared to symptomatic treatments randomly assigned 166 adults diagnosed with acute sinusitis to
one of two groups: treatment or control. Study participants received either a 10-day course of amoxicillin (an
antibiotic) or a placebo similar in appearance and taste. The placebo consisted of symptomatic treatments
such as acetaminophen, nasal decongestants, etc. At the end of the 10-day period, patients were asked if
they experienced improvement in symptoms. The distribution of responses is summarized below.³
Group
Treatment
Control
Total
Self-reported improvement
in symptoms
Yes
66
65
131
No
19
16
35
Total
85
81
166
(a) What percent of patients in the treatment group experienced improvement in symptoms?
(b) What percent experienced improvement in symptoms in the control group?
(c) In which group did a higher percentage of patients experience improvement in symptoms?
(d) Your findings so far might suggest a real difference in effectiveness of antibiotic and placebo treatments
for improving symptoms of sinusitis. However, this is not the only possible conclusion that can be drawn
based on your findings so far. What is one other possible explanation for the observed difference between
the percentages of patients in the antibiotic and placebo treatment groups that experience improvement
in symptoms of sinusitis?
Transcribed Image Text:1.2 Sinusitis and antibiotics, Part I. Researchers studying the effect of antibiotic treatment for acute sinusitis compared to symptomatic treatments randomly assigned 166 adults diagnosed with acute sinusitis to one of two groups: treatment or control. Study participants received either a 10-day course of amoxicillin (an antibiotic) or a placebo similar in appearance and taste. The placebo consisted of symptomatic treatments such as acetaminophen, nasal decongestants, etc. At the end of the 10-day period, patients were asked if they experienced improvement in symptoms. The distribution of responses is summarized below.³ Group Treatment Control Total Self-reported improvement in symptoms Yes 66 65 131 No 19 16 35 Total 85 81 166 (a) What percent of patients in the treatment group experienced improvement in symptoms? (b) What percent experienced improvement in symptoms in the control group? (c) In which group did a higher percentage of patients experience improvement in symptoms? (d) Your findings so far might suggest a real difference in effectiveness of antibiotic and placebo treatments for improving symptoms of sinusitis. However, this is not the only possible conclusion that can be drawn based on your findings so far. What is one other possible explanation for the observed difference between the percentages of patients in the antibiotic and placebo treatment groups that experience improvement in symptoms of sinusitis?
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