1. Proteoglycans, such as heparan sulfate are defined as having sulfated glycosaminoglycans that are covalently joined to membrane proteins or secreted proteins. a. Which weak intermolecular force of attraction allows the proteoglycans to interact with extracellular proteins, such as antithrombin (AT) in the diagram below? b. Provide the full name of the moiety on the proteoglycan that interacts with the protein. c. Provide the name of one of the amino acid residues within the protein (AT) that is likely to interact with the proteoglycan Conformational activation Factor Xa AT Heparan sulfate LNS domain A conformational change induced in the protein antithrombin (AT) on binding a specific pentasaccharide NS domain allows its interaction with blood clotting factor Xa, preventing clotting.
1. Proteoglycans, such as heparan sulfate are defined as having sulfated glycosaminoglycans that are covalently joined to membrane proteins or secreted proteins. a. Which weak intermolecular force of attraction allows the proteoglycans to interact with extracellular proteins, such as antithrombin (AT) in the diagram below? b. Provide the full name of the moiety on the proteoglycan that interacts with the protein. c. Provide the name of one of the amino acid residues within the protein (AT) that is likely to interact with the proteoglycan Conformational activation Factor Xa AT Heparan sulfate LNS domain A conformational change induced in the protein antithrombin (AT) on binding a specific pentasaccharide NS domain allows its interaction with blood clotting factor Xa, preventing clotting.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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