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1. Glucose synthesis was investigated in isolated hepatocytes. Different amino acids were added to the cell culture and the rate of glucose formation was checking in. In control cxperiment, the rate of gluconcogenesis was 0.15 umol/min of glucose formation. When alanine, proline and glutamic acid were introduced to cell culture, the rate of gluconcogenesis was increased to 0.17-0.18 umol/min, but the adding of lysine or leucine had no effect. Why the introduction of certain amino acids increases the rate of new glucosc formation? For the answer: a) write down the process taking alanine as the substrate; b) specify the group to which used in experiment amino acids are related to. cl write down the scheme of eluconcoecnesis originated from tbese amino acids

1. Glucose synthesis was investigated in isolated hepatocytes. Different amino acids were added to the cell culture and the rate of glucose formation was checking in. In control cxperiment, the rate of gluconcogenesis was 0.15 umol/min of glucose formation. When alanine, proline and glutamic acid were introduced to cell culture, the rate of gluconcogenesis was increased to 0.17-0.18 umol/min, but the adding of lysine or leucine had no effect. Why the introduction of certain amino acids increases the rate of new glucosc formation? For the answer: a) write down the process taking alanine as the substrate; b) specify the group to which used in experiment amino acids are related to. cl write down the scheme of eluconcoecnesis originated from tbese amino acids

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. Glucose synthesis was investigated in isolated hepatocytes. Different amino acids wcre added to the cell culture and the rate of glucose formation was chccking in. In control experiment, the rate of gluconcogenesis was 0.15 umol/min of glucose formation. When alanine, proline and glutamic acid were introduced to cell culture, the rate of gluconcogenesis was increased to 0.17-0.18 umol/min, but the adding of lysine or leucine had no effect. Why the introduction of certain amino acids increases the rate of «new glucose» formation? For the answer: a) write down the process taking alanine as the substrate; b) specify the group to which used in experiment amino acids are related to. c) write down the scheme of gluconcogenesis originated from these amino acids.
Transcribed Image Text:1. Glucose synthesis was investigated in isolated hepatocytes. Different amino acids wcre added to the cell culture and the rate of glucose formation was chccking in. In control experiment, the rate of gluconcogenesis was 0.15 umol/min of glucose formation. When alanine, proline and glutamic acid were introduced to cell culture, the rate of gluconcogenesis was increased to 0.17-0.18 umol/min, but the adding of lysine or leucine had no effect. Why the introduction of certain amino acids increases the rate of «new glucose» formation? For the answer: a) write down the process taking alanine as the substrate; b) specify the group to which used in experiment amino acids are related to. c) write down the scheme of gluconcogenesis originated from these amino acids.
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