1. Complete the mechanism for the dehydration of cyclohexanol by adding electron pushing arrows to steps 2 and 3 shown below. What is the role of phosphoric acid? H Step 1: H H OH + H3PO4- . Step 2: H H Step 3: H H OH2 H :0- H H H OH2 + + H2PO4 H H H H مل H H
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- Draw the reactant of the following reaction sequence.4. Propose a mechanism for the following reactions. Explain why different products are formed with different reaction conditions. 1. HCI/H₂O OH Y 2. iPrOK/H₂O 1. HCI/H₂O 2. NaOH/H₂OA useful way to synthesize alkaloids is called the Pictet-Spengler synthesis. The first two steps of the synthesis are shown below. The first step involves a nucleophilic attack, and the second step is a typical elimination reaction. Provide a reasonable mechanism using curved arrows for both reactions.
- Predict the major product of the reaction and draw it in the space provided. + HN. NPh NaBH3CN MeOH/ACOHa) provide the name of each compound in the reaction above, underneath the structure. b) Provide the mechanism of the transformation below. HOH HOH HO CH3OH HO HO HO H -OH H. -OMe H OH cat. HCI OH H OH H1) LiAlH4; ) H3O+ will do which of the following reactions? 3-Phenyl-butanoic acid → 3-phenyl-butan-1-ol Benzene → cyclohexane Benzoic acid → benzaldehyde 2-Phenyl-hexanoic acid → benzoic acid and carbon dioxide 2,3-dimethyl-pent-1-yne → 2,3-dimethyl-pent-1-ene
- Complete the reaction scheme below. Show all reagents and intermediates. No reaction is a possible answer. 1) CH3CH2M9B CH3OH H+ (ехcess) но 2) H30*, H2O B A OCH3Predict the product for the following reaction. 1. Br₂/H₂O 2. NaOH OH Br Br Br OH ميد مير يد سيد IV || OIVProvide an arrow pushing mechanism for the following reaction. Include protons and each step clearly indicated. NH2 O=s=0 H2N NH2 N. N-N Ph Ph Ph Ph HCI, ETOH
- Provide an arrow pushing mechanism for the following reaction. Include protons and each step clearly indicated. Br H. D H3C Hz H3C CH31. Explain why the following cyclohexanol A derivative undergoes E2 more readily than cyclohexanol B. Cyclohexanol A fast t-BUOK "OH Cyclohexanol B slow t-BUOK OHPart 3 Complete the mechanism for the reaction. Mild Acid Draw the mechanism arrows. yh y X See Hint