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1. CH;CH,CH,CH,MgBr а) `CH3 2. H30* (CH;CH2),CuLi b) 1. 2 eq. CH3CH,MgBr c) 2. H2O 1. NABH4 d) 2. H-О 1. СО2 MgBr e) 2. H;O*

1. CH;CH,CH,CH,MgBr а) `CH3 2. H30* (CH;CH2),CuLi b) 1. 2 eq. CH3CH,MgBr c) 2. H2O 1. NABH4 d) 2. H-О 1. СО2 MgBr e) 2. H;O*

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Give the major organic product of the following reactions.(a-e)

### Reaction Descriptions The image contains a series of chemical reactions labeled from a to e, with specific reagents and conditions indicated for each reaction. Here’s a detailed transcription and explanation of each one: #### a) Reaction - **Reactant:** An aromatic ketone with a methyl group (acetophenone). - **Reagents:** 1. \( \text{CH}_3\text{CH}_2\text{CH}_2\text{CH}_2\text{MgBr} \) (butylmagnesium bromide, a Grignard reagent) 2. \( \text{H}_3\text{O}^+ \) (acidic workup) - **Explanation:** Involves nucleophilic addition of the butyl Grignard reagent to the carbonyl group, followed by protonation to give an alcohol. #### b) Reaction - **Reactant:** Chlorinated ketone with an isopropyl group. - **Reagents:** \( (\text{CH}_3\text{CH}_2)_2\text{CuLi} \) (diethylcuprate, a Gilman reagent) - **Explanation:** The Gilman reagent substitutes the chlorine with an ethyl group, possibly through a conjugate addition. #### c) Reaction - **Reactant:** Alkyl chloride with a ketone functional group. - **Reagents:** 1. 2 equivalents of \( \text{CH}_3\text{CH}_2\text{MgBr} \) (ethylmagnesium bromide, a Grignard reagent) 2. \( \text{H}_2\text{O} \) (water for protonation) - **Explanation:** Double addition of ethyl groups via Grignard reagent, followed by hydrolysis. #### d) Reaction - **Reactant:** Aromatic ester with a ketone functional group. - **Reagents:** 1. \( \text{NaBH}_4 \) (sodium borohydride, a reducing agent) 2. \( \text{H}_2\text{O} \) (water for acidic workup) - **Explanation:** Reduction of the ketone to an alcohol. #### e) Reaction - **Reactant:** Alkylmagnesium bromide (GRignard reagent). - **Reagents:**
Transcribed Image Text:### Reaction Descriptions The image contains a series of chemical reactions labeled from a to e, with specific reagents and conditions indicated for each reaction. Here’s a detailed transcription and explanation of each one: #### a) Reaction - **Reactant:** An aromatic ketone with a methyl group (acetophenone). - **Reagents:** 1. \( \text{CH}_3\text{CH}_2\text{CH}_2\text{CH}_2\text{MgBr} \) (butylmagnesium bromide, a Grignard reagent) 2. \( \text{H}_3\text{O}^+ \) (acidic workup) - **Explanation:** Involves nucleophilic addition of the butyl Grignard reagent to the carbonyl group, followed by protonation to give an alcohol. #### b) Reaction - **Reactant:** Chlorinated ketone with an isopropyl group. - **Reagents:** \( (\text{CH}_3\text{CH}_2)_2\text{CuLi} \) (diethylcuprate, a Gilman reagent) - **Explanation:** The Gilman reagent substitutes the chlorine with an ethyl group, possibly through a conjugate addition. #### c) Reaction - **Reactant:** Alkyl chloride with a ketone functional group. - **Reagents:** 1. 2 equivalents of \( \text{CH}_3\text{CH}_2\text{MgBr} \) (ethylmagnesium bromide, a Grignard reagent) 2. \( \text{H}_2\text{O} \) (water for protonation) - **Explanation:** Double addition of ethyl groups via Grignard reagent, followed by hydrolysis. #### d) Reaction - **Reactant:** Aromatic ester with a ketone functional group. - **Reagents:** 1. \( \text{NaBH}_4 \) (sodium borohydride, a reducing agent) 2. \( \text{H}_2\text{O} \) (water for acidic workup) - **Explanation:** Reduction of the ketone to an alcohol. #### e) Reaction - **Reactant:** Alkylmagnesium bromide (GRignard reagent). - **Reagents:**
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