(a) (b) + 1) LDA 2) Ć HH 3) H30* 1) NaOMe 2) H30*

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Predict the major product(s) for the following reactions.

### Transcription of the Chemical Reaction Diagram

#### Reaction (a)
- **Reactants:**
  - Ethyl acetate (CH₃COOCH₂CH₃)
  - Ethyl benzoate (C₆H₅COOCH₂CH₃)

- **Reagents:**
  1. Sodium methoxide (NaOMe)
  2. Hydronium ion (H₃O⁺)

- **Overview:**
  - This reaction involves the use of sodium methoxide followed by acidic work-up with hydronium ion.
  - Likely involves a Claisen condensation, where two ester molecules react to form a β-keto ester.

#### Reaction (b)
- **Reactant:**
  - Cyclohexanone (C₆H₁₀O)

- **Reagents:**
  1. Lithium diisopropylamide (LDA)
  2. Formaldehyde (CH₂O)
  3. Hydronium ion (H₃O⁺)

- **Overview:**
  - The reaction begins with the use of LDA, a strong base, for deprotonation, likely forming an enolate.
  - Follows with the addition of formaldehyde, suggesting an aldol addition or condensation process.
  - Finally, acidic work-up is carried out with hydronium ion.

### Diagram Description

- The diagram shows two separate reactions labeled as (a) and (b).
- Reaction (a) depicts two ester compounds reacting in the presence of sodium methoxide and an acidic environment to undergo a transformation, commonly seen in carbonyl chemistry.
- Reaction (b) illustrates the transformation of cyclohexanone through deprotonation, reaction with formaldehyde, and acidic neutralization, indicative of aldol chemistry. 

These reactions demonstrate fundamental processes in organic synthesis, often utilized in the formation of carbon-carbon bonds and synthesis of complex structures.
Transcribed Image Text:### Transcription of the Chemical Reaction Diagram #### Reaction (a) - **Reactants:** - Ethyl acetate (CH₃COOCH₂CH₃) - Ethyl benzoate (C₆H₅COOCH₂CH₃) - **Reagents:** 1. Sodium methoxide (NaOMe) 2. Hydronium ion (H₃O⁺) - **Overview:** - This reaction involves the use of sodium methoxide followed by acidic work-up with hydronium ion. - Likely involves a Claisen condensation, where two ester molecules react to form a β-keto ester. #### Reaction (b) - **Reactant:** - Cyclohexanone (C₆H₁₀O) - **Reagents:** 1. Lithium diisopropylamide (LDA) 2. Formaldehyde (CH₂O) 3. Hydronium ion (H₃O⁺) - **Overview:** - The reaction begins with the use of LDA, a strong base, for deprotonation, likely forming an enolate. - Follows with the addition of formaldehyde, suggesting an aldol addition or condensation process. - Finally, acidic work-up is carried out with hydronium ion. ### Diagram Description - The diagram shows two separate reactions labeled as (a) and (b). - Reaction (a) depicts two ester compounds reacting in the presence of sodium methoxide and an acidic environment to undergo a transformation, commonly seen in carbonyl chemistry. - Reaction (b) illustrates the transformation of cyclohexanone through deprotonation, reaction with formaldehyde, and acidic neutralization, indicative of aldol chemistry. These reactions demonstrate fundamental processes in organic synthesis, often utilized in the formation of carbon-carbon bonds and synthesis of complex structures.
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