1. Both natural selection and genetic drift can reduce heterozygosity (H). At what allele frequency does a population display maximum heterozygosity? Demonstrate this by making a plot to show how H changes as the value of p and q change (remember that p + q = 1.0) and 2pq = H. [hint: make a spread sheet.] 2. Make a graph of H during selection against a recessive. Use the equation: Aq = (spq2)/(1-sq²) Start with the value of p = 0.10, s = 0.50. Make a spreadsheet of the equation, and plot the value of 2pq as the frequency of p and q change during selection. Does this plot confirm what you derived in question 1? 3. The loss of heterozygosity due to genetic drift is given by: Hg+1 = Hg * [1-(1/2N)]; where N is the population size. Begin with H = 0.500. Show that there is a more rapid loss of H with population size 50, compared to population size 250. Hint: make a spreadsheet that computes H across generations, make a graph for each population size and compare them. Why do you think that the loss of H during drift is likely be increase the likelihood of rare genetic diseases in any population (species)?

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
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Chapter19: Evolutionary Change In Populations
Section: Chapter Questions
Problem 3TYU: The MN blood group is of interest to population geneticists because (a) people with genotype MN...
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1. Both natural selection and genetic drift can reduce heterozygosity (H). At what allele
frequency does a population display maximum heterozygosity? Demonstrate this by
making a plot to show how H changes as the value of p and q change (remember that p
+ q = 1.0) and 2pq = H. [hint: make a spread sheet.]
2. Make a graph of H during selection against a recessive. Use the equation:
Aq = (spq2)/(1-sq²)
Start with the value of p = 0.10, s = 0.50. Make a spreadsheet of the equation, and plot
the value of 2pq as the frequency of p and q change during selection.
Does this plot confirm what you derived in question 1?
3. The loss of heterozygosity due to genetic drift is given by:
Hg+1 = Hg * [1-(1/2N)]; where N is the population size. Begin with H = 0.500.
Show that there is a more rapid loss of H with population size 50, compared to population size
250. Hint: make a spreadsheet that computes H across generations, make a graph for each
population size and compare them.
Why do you think that the loss of H during drift is likely be increase the likelihood of rare
genetic diseases in any population (species)?
Transcribed Image Text:1. Both natural selection and genetic drift can reduce heterozygosity (H). At what allele frequency does a population display maximum heterozygosity? Demonstrate this by making a plot to show how H changes as the value of p and q change (remember that p + q = 1.0) and 2pq = H. [hint: make a spread sheet.] 2. Make a graph of H during selection against a recessive. Use the equation: Aq = (spq2)/(1-sq²) Start with the value of p = 0.10, s = 0.50. Make a spreadsheet of the equation, and plot the value of 2pq as the frequency of p and q change during selection. Does this plot confirm what you derived in question 1? 3. The loss of heterozygosity due to genetic drift is given by: Hg+1 = Hg * [1-(1/2N)]; where N is the population size. Begin with H = 0.500. Show that there is a more rapid loss of H with population size 50, compared to population size 250. Hint: make a spreadsheet that computes H across generations, make a graph for each population size and compare them. Why do you think that the loss of H during drift is likely be increase the likelihood of rare genetic diseases in any population (species)?
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