1. Both natural selection and genetic drift can reduce heterozygosity (H). At what allele frequency does a population display maximum heterozygosity? Demonstrate this by making a plot to show how H changes as the value of p and q change (remember that p + q = 1.0) and 2pq = H. [hint: make a spread sheet.] 2. Make a graph of H during selection against a recessive. Use the equation: Aq = (spq2)/(1-sq²) Start with the value of p = 0.10, s = 0.50. Make a spreadsheet of the equation, and plot the value of 2pq as the frequency of p and q change during selection. Does this plot confirm what you derived in question 1? 3. The loss of heterozygosity due to genetic drift is given by: Hg+1 = Hg * [1-(1/2N)]; where N is the population size. Begin with H = 0.500. Show that there is a more rapid loss of H with population size 50, compared to population size 250. Hint: make a spreadsheet that computes H across generations, make a graph for each population size and compare them. Why do you think that the loss of H during drift is likely be increase the likelihood of rare genetic diseases in any population (species)?

1. Both natural selection and genetic drift can reduce heterozygosity (H). At what allele frequency does a population display maximum heterozygosity? Demonstrate this by making a plot to show how H changes as the value of p and q change (remember that p + q = 1.0) and 2pq = H. [hint: make a spread sheet.] 2. Make a graph of H during selection against a recessive. Use the equation: Aq = (spq2)/(1-sq²) Start with the value of p = 0.10, s = 0.50. Make a spreadsheet of the equation, and plot the value of 2pq as the frequency of p and q change during selection. Does this plot confirm what you derived in question 1? 3. The loss of heterozygosity due to genetic drift is given by: Hg+1 = Hg * [1-(1/2N)]; where N is the population size. Begin with H = 0.500. Show that there is a more rapid loss of H with population size 50, compared to population size 250. Hint: make a spreadsheet that computes H across generations, make a graph for each population size and compare them. Why do you think that the loss of H during drift is likely be increase the likelihood of rare genetic diseases in any population (species)?

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter19: Evolutionary Change In Populations

Section: Chapter Questions

Problem 3TYU: The MN blood group is of interest to population geneticists because (a) people with genotype MN...

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