1) Use the Leontis-Westhof base pair classification to identify the interaction occurring betweeneach of the base pairs formed in the image below:

Answered: 1) Use the Leontis-Westhof base pair…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

1) Use the Leontis-Westhof base pair classification to identify the interaction occurring between
each of the base pairs formed in the image below:

Expert Solution

Introduction

Leontis-Westhof base pair classification is a system that categorizes RNA base pairs based on the identities and relative orientations of the bases involved. The classification system was developed by Eric Westhof and Neocles Leontis in the 1990s, and it has become a widely used standard for describing RNA structures.

The Leontis-Westhof classification system divides RNA base pairs into three categories based on their geometry and the types of hydrogen bonds that form between the bases:

Watson-Crick base pairs: These base pairs are formed between complementary bases (A-U, U-A, G-C, C-G) and are characterized by the presence of three hydrogen bonds between the bases. Watson-Crick base pairs are essential for the double-helical structure of RNA.
Non-Watson-Crick base pairs: These base pairs are formed between non-complementary bases and are characterized by one or two hydrogen bonds between the bases. Non-Watson-Crick base pairs are important for stabilizing RNA tertiary structures.
Non-canonical base pairs: These base pairs are formed between modified or rare bases and are characterized by unique hydrogen bond patterns. Non-canonical base pairs play important roles in RNA folding and function.