. It is thought that the signal for eukaryotic mismatch repair, for iden-tifying the strand to be repaired, could be nicks in the DNA to berepaired. If so, would you expect the nicked strand or the intactstrand to be the strand to be repaired? Briefly explain your answer.

DNA : it is the molecule that contains the genetic code of organisms. DNA is in each cell in the…

Answered: . It is thought that the signal for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Single-strand binding proteins keep the two parental strands of DNA separated from each other until DNA polymerase has an opportunity to replicate the strands. Suggest how single-strand binding proteins keep the strands separated and yet do not impede the ability of DNA polymerase to replicate the strands.
Explain
Collisions between DNA polymerase and a slower-moving RNA polymerase using the same template strand may be responsible for the observation that leading strand synthesis in bacteria is discontinuous in vivo. Draw a diagram to show how DNA synthesis that has been halted after the DNA polymerase–RNA polymerase collision can resume using the RNA transcript as a primer.
Describe how helicase, topoisomerase, and single-strand binding protein are important for the unwinding of the DNA double helix.
You have used the technique of chromatin immunoprecipitation to isolate DNA fragments containing a DNA-binding protein of interest. Suppose that you wish to know whether a particular known DNA fragment is present in the isolated mixture. How might you detect its presence?
Please fill all
If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine
In eukaryotes, what is meant by the term DNA replication licensing? How does the process occur?
1) The function of ligase is to seal nicks in the backbone of a DNA strand. The function of AP endonuclease is to create a nick in the backbone of a DNA molecule adjacent to an apurinic site, which allows DNA polymerase II access to the DNA to repair the damage and prevent a mutation resulting from the use of a damaged or erroneous strand of DNA as template during DNA replication. Why doesn't ligase simply seal up the nicks the AP endonuclease introduces before DNA pol II can do anything?
, Describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Extracts from a strain of bacteria lacking helicase
DNA polymerases cannot act as primers for replication, yet primase and other RNA polymerases can. Some geneticists have speculated that the inability of DNA polymerase to prime replication is a result of its proofreading function. This hypothesis argues that proofreading is essential for the faithful transmission of genetic information and that because DNA polymerases have evolved the ability to proofread, they cannot prime DNA synthesis. Explain why proofreading and priming functions in the same enzyme might be incompatible.

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. It is thought that the signal for eukaryotic mismatch repair, for iden- tifying the strand to be repaired, could be nicks in the DNA to be repaired. If so, would you expect the nicked strand or the intact strand to be the strand to be repaired? Briefly explain your answer.