Week 6 Experimental Studies Participation Activity

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California State University, Fullerton *

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MISC

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Medicine

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Dec 6, 2023

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docx

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Week 6 – Experimental Studies Participation Activity For this activity, you may work individually or with one other classmate . If you work with a classmate, both names need to be on the submission or I can only give credit to the student who submitted it. This is worth 17 participations points. It is due on Sunday, 10/6 @ 11:59pm. Late submissions will be accepted up to 2 days after with a 10% penalty each day (ie. up to 20%). Part I: Video (5 points) x Please watch the video titled “A History of Clinical Research” presented by Dr. Dennis Gillings posted as STEP 3A on the course Titanium page. It can also be found at the following URL: https://www.youtube.com/watch?v=vYBtlItAT3c&t . Based on the video, answer the following questions. You will be graded on accuracy and thoughtfulness of your answers. 1. Discuss two specific historical examples of medicine or clinical research mentioned by Dr. Gillings. (maximum 1-2 sentences for each) (2 points) In Egypt in the 1500s a doctor would prescribe powdered wood for an eye infection but no one would know because clinical trials were not a thing yet. In 1796, Edward Jenner proved that inoculation could prevent small pox. 2. According to Dr. Gillings, how many novel drug therapies has the FDA approved? (1 point) The FDA has 1,019 drugs therapies to this today. 3. Why do you think clinical trials are important when it comes to public health? Explain your answer. (2 points) The clinical trials are important today because even though we may have current treatments to many of the known medical diagnoses, there might be a better course of treatment. With clinical trials, we would be able to compare and contrast the benefits and disadvantages of a potential new treatment. Part II: Real-Life Experimental Studies (12 points) Please read the two real-life experimental study articles posted as STEP 3B and STEP 3C on the course Titanium page. Then, answer the following questions. You will be graded on accuracy and thoughtfulness of your answers. 1. For each experimental study, what is the exposure? In other words, what were the researchers testing on the participants? No explanations are needed. For example, if the study was looking at the effects of smoking on risk of getting lung cancer, the exposure would be smoking. (2 points)
Study #1 – Exposure: The exposure would be computer/classroom courses to prevent the rate of alzhemier’s/dementia. Study #2 – Exposure: The exposure would be effects of amyloids in association with alzheimers. 2. For each experimental study, what is the outcome being measured? In other words, what were the researchers specifically evaluating as a result of giving the participants the exposure? No explanations are needed. For example, if the study was looking at the effects of smoking on risk of getting lung cancer, the outcome would be lung cancer risk. (Note: This is NOT asking for the study’s results) (2 points) Study #1 – Outcome: The outcome is determining the most effective Alzheimer’s prevention. Study #2 – Outcome: The outcome is determing the significance of amyloids in treating Alzheimer patients. 3. For each experimental study, briefly discuss how each study was conducted. Your answer should mention who was recruited, what specific exposure groups were compared, and what the researchers used to determine the outcome being measured. Remember, the outcome is not the study’s results. (4 points) Study #1 – Recruited Population: Older population people with an average age of 73.4 when the study started. Study #1 – Exposure Comparison Groups: One group got a classroom-based course designed to impart strategies aimed at boosting memory, the second got a classroom- based course designed to sharpen participants’ reasoning skills, and the third group was given computerized training designed to increase the speed at which the brain picks up and processes cues in a person’s field of vision. Study #1 – How the Outcome was Measured: The outcome was measured at the 1, 2, 3, 5, and 10 year mark. They used standardized batteries such as participant’s mood and ability to be independent. Study #2 – Recruited Population: The recruited population was people with alzheimer’s who had amyloids. Study #2 – Exposure Comparison Groups: There was a group that was receiving a placebo drug and one that was receiving the actual drug. Study #2 – How the Outcome was Measured: They used medical machines to measure tha amount of amyloid plaque in the brain. 4. Which level of prevention best describes each experimental study? No explanations are needed. (2 points)
Study #1 Level of Prevention: Secondary Study #2 Level of Prevention: Tertiary 5. Even though you don’t qualify for either study, if you had to pick one study to participate in, which would you choose and why? Think about the exposure, what’s required of you as a participant as well as any other details you might consider before making such a decision. Explain your answer. (2 points) Your Choice: I would choose the Alzheimer’s study (Study 1). Explanation: I would choose this because losing my memory and daily life functions is something I fear and knowing there is no way to alter the course of the disease when you get diagnosed with it is scary. This study does not require the most effort as you would either go to a class or do an online activity so it would be easy to keep on track of it.
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