Gout Naplex Review Questions

Gout Naplex Review Questions Question 1: A 68-year-old man presents to the clinic with a history of three acute episodes of gout in the past year. He is classified as an overproducer of uric acid. He has severe liver impairment but no renal insufficiency. Which of the following medications is appropriate for chronic prophylaxis of gout? A) Allopurinol B) Febuxostat C) Probenecid D) Sulfinpyrazone Question 2: Which statement is true regarding febuxostat ? A ) Febuxostat is a good choice for patients with liver failure. B ) Febuxostat is the drug of choice for acute gout. C ) Febuxostat is an option for patients with renal insufficiency. D ) Febuxostat has no drug interactions. Question 3: A 76-year-old woman with a 10-year history of gout presents to the clinic with painful monosodium uric (MSU) crystal deposits in her hand. Which of the following terms most accurately describes this complication of gout? A ) Atheromas B ) Podagra C ) Tophi D ) Uric acid nephrolithiasis Question 4:

A 72-year-old man presents to your community pharmacy to pick up a new prescription for indomethacin . It was prescribed by an urgent care clinic for an acute gout attack in his left knee. After reviewing his medication profile, you see that he is also being treated for a recent gastrointestinal (GI) bleed with a proton pump inhibitor (PPI) prescribed by a GI specialist. His past medical history also includes hypertension, type 2 diabetes, and chronic kidney disease. What is the best course of action to take? A ) Fill the script as the patient is currently being covered by a PPI. B ) Contact the prescriber to verify that they were aware of the patient's past medical history and discuss if they want to continue the nonsteroidal anti- inflammatory drug (NSAID) therapy. C ) Contact the prescriber to verify that they were aware of the patient's past medical history and recommend to switch the patient to a corticosteroid D ) Contact the prescriber to verify that they were aware of the patient's past medical history and recommend to switch the patient to colchicine Question 5: Select the target serum uric acid (SUA) level when treating gout. A) ≤6 mg/dL B) ≤7 mg/dL C) ≤8 mg/dL D) ≤9 mg/dL Question 6: Which agent has special handling precautions? A ) Allopurinol B ) Febuxostat C ) Colchicine D ) Prednisone Question 7:

Which of the following is a true statement regarding allopurinol drug interactions? A) Use of allopurinol increases warfarin levels and increases theophylline levels. B) Use of allopurinol increases warfarin levels and decreases theophylline levels. C) Use of allopurinol decreases warfarin levels and decreases theophylline levels. D) Use of allopurinol decreases warfarin levels and increases theophylline levels. Question 11: A 60-year-old man presents to the pharmacy with a past medical history of hypertension and gout. After reviewing his medication profile, which medication is most likely to cause elevated serum uric acid (SUA) levels? A) Hydrochlorothiazide B) Losartan C) Amlodipine D) Indomethacin Question 12: What is the mechanism of action by which probenecid produces its effect? A) Inhibition of xanthine oxidase B) Blocks excretion of uric acid C) Blocks reuptake of uric acid at the proximal tubule D) Inhibits prostaglandin synthesis Question 13: JJ is a patient who is receiving medication therapy management services from your pharmacy. Since he has a past medical history of gout, which of the following foods should you counsel him to avoid eating as it contains a high purine content? A) Liver B) Apple C) Popcorn

D) Potatoes Question 14: Which statement most accurately describes the mechanism of nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of gout? A ) NSAIDs work by reducing phagocytosis and lactic acid production in joints, thereby reducing deposition of urate crystals. B ) NSAIDs work by blocking the conversion of xanthine to uric acid. C ) NSAIDs work by exerting anti-inflammatory, analgesic, and antipyretic effects by inhibiting the synthesis of prostaglandin. D ) NSAIDs work by inhibiting proximal renal tubule reabsorption of uric acid to decrease serum levels. Question 15: A 63-year-old man presents to your clinic complaining of excruciating pain in his left big toe. After being diagnosed with an acute gout flare, his physician wants to start him on therapy. His medical history is positive for hypertension, hyperlipidemia, peptic ulcer disease, and glaucoma. Which of the following is the most appropriate therapy at this time for the patient? A ) Ibuprofen B ) Indomethacin C ) Allopurinol D ) Prednisone Question 16: A patient is picking up a new prescription for colchicine . Select the most appropriate counseling point to discuss with the patient. A) The patient should be counseled on gastrointestinal side effects of nausea, vomiting, diarrhea, and abdominal pain. B) The patient should be counseled on the possibility of a rash. C) The patient should be counseled on signs and symptoms of bleeding. D) The patient should be counseled on close monitoring of blood glucose levels.