Week 15

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School

University of New England *

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Course

1005

Subject

Chemistry

Date

Jan 9, 2024

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docx

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4

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Week 15 Question 1 (1 point) In pyrimidine synthesis, uridine triphosphate (UTP) can feedback and inhibit which of the following enzymes? Question 1 options: Thymidylate synthase Carbamoyl phosphate synthase II*** Aspartate transcarbamylase Dihydrooratase Question 2 (1 point) An elevation of purine nucleotides will negatively regulate pyrimidine synthesis through which of the following mechanisms? Question 2 options: Inhibiting the activity of carbamoyl phosphate synthetase II (CPSII)*** Inhibiting the activity of thymidylate synthase Increasing degradation of pyrimidine bases Increasing the activity of the non-oxidative reactions of the pentose pathway Question 3 (1 point)
Methotrexate (image below) is classified as an "antimetabolite." Methotrexate most closely resembles which endogenous compound? Question 3 options: 5-hydroxytryptamine Folate*** Aspartic acid Histamine Epinephrine Question 4 (1 point) Which of the following compounds contributes both the sugar and phosphate groups to the nucleotide bases? Question 4 options: PRPP (5- phosphoribosylpyrophosphate)*** 5- methyl thymidine Inosine monophosphate
Glucose 6-phosphate Question 5 (1 point) Which of the following is the common intermediate for pyrimidine synthesis? Question 5 options: Hypoxanthine Cytidine monophosphate (CMP Inosine monophosphate (IMP) Uridine monophosphate (UMP)*** Question 6 (1 point) Saved Methotrexate is a potent anticancer agent that starves dividing cells of deoxyribonucleotides through direct inhibition of which of the following processes? Question 6 options: Degradation of purine bases to uric acid Deoxygenation of the ribose ring to produce deoxyribose for DNA Metabolism of folic acid*** Synthesis of purine bases Synthesis of thymidine
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Question 7 (1 point) Saved The ribonucleotide reductase is important for converting ribose bases to the deoxy form. This conversion is coupled with the oxidation of which of the following compounds? Question 7 options: NADP+ Tetrahydrofolate Thioredoxin*** NADH Question 8 (1 point) Which of the following best describes why purines are recycled? Question 8 options: They are utilized to a greater extent when compared to pyrimidines They are required to a greater extent for DNA synthesis They cannot be endogenously synthesized The double ring structure is difficult to enzymatically break***