Lab Report one

HW 10 #16  need help on the last question

Q5. A. Complete the incomplete reactions. Also write stepwise mechanism for the given reactions. CH3 i. BH3, THE ii. H2O2, HO Br H20 ii. H3C OH H. H3C Br Br2, H20 CH3 Br OH organic solvent CH3 КОН CI V. + CHCI3 KCI CI

In both examples below the reactants shown are combined to bring about a nucleophilic substitution (S1, Sy2) and'or elimination (EI, E2) reaction What is the major reaction that takes place in each case? CH, CH, CH,CH,CHCCH, H20 Br NaNg CH,OH CH,CH,CHCH,CH, SN2

4. A CHEM 245 student wants to synthesize some ethylene glycol to use as antifreeze in his radiator this winter. He proposes the following reaction to his instructor, who quickly explains that this reaction won't work as proposed due to the student's choice of reagent. 1) NaH 2) H20 OH Но a) Why can't sodium hydride (NaH) be used as the nucleophile in the reaction above? b) Propose an alternate reagent that COULD be used with the ethylene oxide to successfully give the desired ethylene glycol product.

The mechanism proceeds through a first cationic intermediate, intermediate 1. Nucleophilic attack leads to intermediate 2, which goes on to form the final product. In cases that involve negatively charged nucleophile, the attack of the nucleophile leads directly to the product. H. Br + CH3OH Br Intermediate 2 (product) Intermediate 1 In a similar fashion, draw intermediate 1 and intermediate 2 (final product) for the following reaction. OCH3 Cl2 MEOH ĆI racemic mixture Pay attention to the reactants, they may differ from the examples. In some reactions, one part of the molecule acts as the nucleophile. • You do not have to consider stereochemistry. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate intermediate 1 and intermediate 2 using the the dropdown menu. → symbol from

See Figure 9-8. Alkene 1 can be formed by an E2 reaction of alkyl halide [Select] Alkene 2 can be formed by an E2 reaction of alkyl halide [Select] Alkene 3 can be formed by an E2 reaction of alkyl halide [Select] Figuna 9-8 Alkanes Alkyl halides Br. 1 A trăto 3 Br t तु Br

Draw the structure of the product of the reaction shown above.

Question 10 Select the major product of the reaction sequence below. OH CH,CH,CCN CH,CH, OH CH,CH,CCH,CH, CO,H 1. (CH,CH2)2CULI CH,CH,CI 2. NaCN / H* 3. LIAIH4, then H2O CH,CH, CH,CH,CH,NH, ČH,CH3 OH CH,CH,CCH,NH, CH,CH3 D B. C

2. Fill in the boxes with the reactants, reagents, or products for each reaction. Underneath each reaction, propose a complete mechanism for the transformation. NH2 1. CH31 (excess) 2. Ag20 3. heat Ph

Chapter 16 End of Chapter, Out of Class As I promised, this is basically just some more synthesis practice. O₂N OH CN OH from Benzene from Benzene From Toluene

Identify the missing reagent(s), reactant(s) or final product(s). Some transformations may require more than one step. Br ? Br D. E. in ? ? LIAIH

What is the major product of the shown reaction ? 1.) BD3 2.) D2Ó2 H H D D CEC-H D D A D D D D Deuterium (chemical symbol - D) is a heavy isotope of hydrogen. C O1.A O 2. C 3. this reaction won't proceed as shown O5. B

I need the reaction mechanism of this step

7. What is/are the major product(s) of the following reactions? A. B. C. d. Et Br 1. mcpba 2. CH3MgCl 1. 2. H30* 1. MCPBA (aka RCO3H) MgBr 2. 3. H30* MgBr 1. Mg 요 2. 3. H30* 4. PCC