TRIMYRISTIN POST LAB

What method of separation would you use to isolate compound B from an ether solution containing a mixture of the two compounds below? OH A B Extract with base, isolate the aqueous layer, neutralize with acid, filter the precipitate and dry Extract with acid, isolate the aqueous layer, neutralize with base, filter the precipitate and dry Extract with base, isolate the organic layer, dry with magnesium sulfate, and evaporate the solvent Extract with acid, isolate the organic layer, dry with magnesium sulfate, and evaporate the solvent Extract with base, isolate the organic layer, neutralize with acid, filter the precipitate and dry Extract with acid, isolate the organic layer, neutralize with base, filter the precipitate and dry

TRUE OR FALSE, if false then give the correct word to make the statement true then explain 1. Sublimation occurs when a solid has a relatively high vapor pressure at a temperature [above] its melting point. 2. To isolate the desired chemical, a single extraction is [more efficient] than extracting the compound numerous times. 3. The compounds are separated in liquid-liquid extraction based on their relative solubilities in two [immiscible] liquids.

please solve question 1 and 2, thanks alot sir for ur help, note that this is not a graded question, its a past paper

1. A vial containing an unknown sample is suspected to be one of the following compounds (mp.): urea (~133 °C), 2,4-dimethylacetanilide (~133 °C), phenacetin (~134°C) or 3-chlorobenzamide (~134 °C). A list of melting points taken on a machine when the 50% of the unknown by volume has been mixed with 50% each of the possibilities is shown in the following table: Melting point (°C) of mixture Substance mixed with unknown (50% each) urea 133.5-134.0 2,4-dimethylacetanilide phenacetin 3-chlorobenzamide 108.6-128.1 105.7-120.4 120.3-130.5 Identify the unknown and explain your reasoning, using the notes you have taken in the lab.

Using chemical structures, illustrate the differences in weak intermolecular interactions that would occur between both propane and 1-propanol and Carbowax 20M, a polyethylene glycol material. Draw a structure of the polyethylene glycol material to illustrate these interactions. Which of the two compounds do you expect to have longer retention time? Explain.

What is the purpose of washing the crude product with petroleum ether before filtration?

Diethyl ether and methylene chloride are generally not suitable for use in recrystallization, but are frequently used as extraction solvents. Explain

1. A student wants to dry a solution of aniline in hexane. Which drying agent should he use for the task? Rationalize the choice. 2.  If calcium oxide is used as a drying agent, what is obtained as a product? 3. Why is ill-advised to use P4O10 as drying agents for “wet” acetone?

D Question 3 The purpose of the capillary 'air bleed' in the distillation step is: O to ensure a smooth distillation and minimize 'bumping' of the crude material during heating o to allow any volatile materials to escape and not be trapped with the distilled product O to make sure the vacuum isn't too great O to make sure the vacuum isn't too weak

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.Your colleague is helping you develop the urine test. They suggest that the urine should be adjusted to a pH above 7 before extracting with the organic solvent. Why is this necessary? Support your explanation with a full arrow-pushing mechanism for the reaction that would occur if the pH was below 7. Include all formal charges, intermediates (if applicable) and products.

Extraction of the aqueous salicylic acid solutions with 10% ethyl acetate/hexane (density ~ 0.7 g/ml) will give two layers in the separatory funnel. Will the aqueous layer be the upper layer or the lower layer?   If dichloromethane (density ~ 1.3 g/ml) were substituted for the 10% ethyl acetate/hexane solution, which layer would be the aqueous layer?