Lab 5 - Quantative Inheritance - Student Atlas, Fall 2023

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New York University *

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Biology

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Jan 9, 2024

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Quantitative Inheritance Atlas Human Genetics Fall 2023 Name: Noor Maahin Lab Instructor: Mrunmayi More Section time/day: 7, Thursday 11:00 – 12:15
Population Split, Heritability: MEDIUM Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
High or Low Spot Number Population, Heritability: LOW Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
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High or Low Spot Number Population, Heritability: MEDIUM Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
High or Low Spot Number Population, Heritability: HIGH Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
High and Low Spot Numbers (Bimodal) Population, Heritability: LOW Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
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High and Low Spot Numbers (Bimodal) Population, Heritability: HIGH Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
UNKNOWN HERITABILITY Initial Population Initial Spot Distribution Final Populations Final Spot Distributions Selected Population Selected Spot Distribution
LAB QUESTIONS Question 1: The number of different phenotypes under this kind of additive model is 2n+1, where n is the number of loci. How many loci are required to make the 15 different phenotypes corresponding to 0–14 spots? - You need 7 loci to generate 15 different phenotypes from 0-14 spots in a simple additive model Question 2: Assume you know the value of h2. How would you calculate the fraction of phenotypic variation due to environment, VE/VP, in terms of h2? - You can calculate the fraction of phenotypic variation due to the environment (VE/VP) in terms of heritability (h²) using the equation: VE/VP = 1 - h²
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LAB QUESTIONS Question 3: In one sentence, describe how heritability affects evolution of the mean phenotype in the selected population (Right Field) relative to the original population (Left Field). - The lower the heritability, the closer the selected population (right field) can get to the original population’s (left field) mean. Question 4: In one sentence, describe what happens to the distribution over a few generations if you start a population with ladybugs that have low and high numbers of spots but no bugs with a medium number of spots. - This will result in a higher concentration of ladybugs with a spot number close to the mean, compared to the original population
LAB QUESTIONS Question 5: Record your values of x 1 , x 2 and show how you calculated S. X 1 =9.16 x 2 = 6.97 S = x 2 - x 1 --> S= -2.19 Question 6: Show how you calculated R. R = Y 2 – x 2 = 7.28 – 9.16 = -1.88 Question 7: What is your estimated heritability? h 2 = R/S h 2 = (-1.88) /(- 2.19) h 2 = 0.86
LAB QUESTIONS Question 8: Draw conclusions about your experiment. For example: § Is your calculated value of h 2 high or low? § How much did the mean of the population change when you selected parents with extreme phenotypic values? Does this behavior match well with your selection tests using different known heritabilities? Why or why not? § Does the Breeder's Equation give a good prediction about how strongly selection will work on a particular quantitative trait? § Are there any questions you could propose to test in the future to increase our understanding of how heritability affects the strength of selection (or other aspects of quantitative inheritance explored here)? Continue Answer on Next Page…
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LAB QUESTIONS 1. My calculated value of h 2 is high, as it is 0.86 2. The mean of a population changes significantly more when selecting parents with extreme phenotypic values. This behavior matches well with my selection tests using different phenotypic values because those values seemed to stay relatively the same. When looking comparatively at the extreme populations and the random populations, the random populations have means closer to the that of the original population as the phenotypes are relatively scattered. Though, extreme populations have higher means compared to the original mean because the phenotypes are more concentrated. 3. Yes, because the Breeder's Equation provides a valuable framework for understanding and predicting the response to selection for a quantitative trait, especially when applied to well-defined and controlled breeding programs. 4. A few questions we can ask: 1. How does the response to selection change across traits with varying heritabilities, and what is the relationship between heritability and the rate of response to selection? 2. How does population size, and its impact on genetic drift, affect the effectiveness of selection, especially for traits with low heritability?