Copy of INFO 4 Mutation analysis problem KEY

docx

School

University of Notre Dame *

*We aren’t endorsed by this school

Course

50133

Subject

Biology

Date

Apr 3, 2024

Type

docx

Pages

1

Uploaded by DeanStarOwl18

Report
Mutation analysis problem Consider a gene for which there are several known mutants. The normal mRNA transcript and each mutant transcript are listed below. Mutations are indicated in bold and underlined . 1. Use your codon table to translate the transcripts into amino acid sequences. 2. Classify the type of mutation: missense, nonsense, silent, or frameshift 3. Predict whether the mutation would likely alter the structure (and therefore function) of the protein. mRNA transcript Type of mutation Alter protein structure? Normal: 5’AUG|AAG|UUU|GGC|UAA3’ Met Lys Phe Gly Stop NA NA Mutant 1: 5’AUG|AAG| UU C | GGC|UAA3’ Phe Silent Phe → Phe NO: Does not change amino acid sequence. Mutant 2: 5’AUG|AAG|UUU| G A C| UAA3’ Asp Missense Gly → Asp Likely YES: Change uncharged to charged amino acid. Mutant 3: 5’AUG|AAG|UUU| G U C |UAA3’ Val Missense Gly → Val MAYBE?: Gly and Val are both small non-polar amino acids. Mutant 4: 5’AUG| U AG |UUU|GGC|UAA3’ stop Nonsense Lys → STOP YES: Only 1 amino acid is translated because of premature stop. U deleted Mutant 5: 5’AUG|AAG| UUG|GCU|AAC 3’ Leu Ala Asn Frameshift YES: Change in several amino acids and no longer a stop codon.
Discover more documents: Sign up today!
Unlock a world of knowledge! Explore tailored content for a richer learning experience. Here's what you'll get:
  • Access to all documents
  • Unlimited textbook solutions
  • 24/7 expert homework help

Related Documents

8_Proj_S23.docx
Projects Six and Seven.docx
Zoology Lab Tutorial Assignment.docx
MCCG150 Week 5 Initial Discussion post.docx
PAGE and Western Blot Practice Sheet_Answer Key.pdf
EXAM 3 - practice .pdf
Practice Questions.pdf
Practice Questions.docx
Copy of INFO 4 Transcription and translation application problem and KEY.docx
Culinary Fundamentals HW #18.docx
Exemplar_Assignment 3.docx
Kreider Leaf litterWrite-Up.docx
Recommended textbooks for you
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
Text book image
Anatomy & Physiology
Biology
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:OpenStax College
SEE MORE TEXTBOOKS
Recommended textbooks for you
  • Text book image
    Human Heredity: Principles and Issues (MindTap Co...
    Biology
    ISBN:9781305251052
    Author:Michael Cummings
    Publisher:Cengage Learning
    Text book image
    Biochemistry
    Biochemistry
    ISBN:9781305577206
    Author:Reginald H. Garrett, Charles M. Grisham
    Publisher:Cengage Learning
    Text book image
    Biology: The Dynamic Science (MindTap Course List)
    Biology
    ISBN:9781305389892
    Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
    Publisher:Cengage Learning
  • Text book image
    Biology 2e
    Biology
    ISBN:9781947172517
    Author:Matthew Douglas, Jung Choi, Mary Ann Clark
    Publisher:OpenStax
    Text book image
    Biology (MindTap Course List)
    Biology
    ISBN:9781337392938
    Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
    Publisher:Cengage Learning
    Text book image
    Anatomy & Physiology
    Biology
    ISBN:9781938168130
    Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
    Publisher:OpenStax College
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
Text book image
Anatomy & Physiology
Biology
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:OpenStax College
SEE MORE TEXTBOOKS