1). Circle/Highlight the correct mode of transmission for this disorder (1point):
X-linked Recessive Autosomal Recessive
Y-linked X-linked Dominant
Autosomal Dominant Epistatic
3). What is the probability that II-5 is a carrier of this disorder? Show your work with a Punnett Square in addition to stating the probability.
(1 points total, 0.5 point for work and 0.5 point for correct answer). Hint: We know the sex of II-5 and we know II-5 has an affected sibling.
2). Circle/Highlight ALL the potential genotype(s) of the based on the pedigree for the following individuals (1 point): X
M = X-linked Dominant
X
m
X = X-linked Recessive Carrier
X
m
X
m
= X-linked Recessive Affected
I-2: MM / Mm / mm / X
M
X
/ X
m
X / X
m
X
m / XX / X
M
Y / X
m
Y / XY
II-3: MM / Mm / mm / X
M
X / X
m
X / X
m
X
m / XX / X
M
Y / X
m
Y / XY
III-4: MM / Mm / mm / X
M
X / X
m
X / X
m
X
m
/ XX / X
M
Y / X
m
Y / XY
IV-1: MM / Mm / mm / X
M
X / X
m
X / X
m
X
m / XX / X
M
Y / X
m
Y / XY
4). If III-2 and III-3 have another child, what is the probability that they have a male child that will have the disorder? Show your work with a Punnett Square, in addition to stating the probability. (2 points total, 1 point for work and 1 point for correct answer)
Hint:
Remember to factor in the probability of having a male child if the mode of transmission is sex-linked.
5) IV-3 goes on an exotic vacation and meets the love of their life, Giselle. It is determined that 14% of the XX population where Giselle lives is a carrier for this disorder. If we assume Giselle has the same risk of being a carrier as everyone else in their population (14%), what is the probability that IV-3 and Wendy will have a male with the disorder? Show your work (via math and/or Punnett squares, 1 point) in addition to stating the final probability (1 point). (2 points total)
Hint:
You will need to determine all the following information in order to calculate the final answer.
The probability that Giselle is a Carrier:
The probability that Giselle passes on a recessive allele: The probability that an XX individual and an XY individual will have a XY child: Final Probability that IV-3 and Wendy would have an affected male child:
