Chapter SRP, Problem 17P

Show how you would modify the synthesis given in the previous problem to synthesize the following drugs:

(a) Bromodiphenhydramine (an antihistamine), where

${\text{R}}_{\text{1}}=\text{Br,}{\text{R}}_2=\text{H}$

(b) Orphenadrine (an antispasmodic, used in controlling Parkinson’s disease), where

${\text{R}}_{\text{1}}=\text{H,}{\text{R}}_2={\text{CH}}_3$