The blood-brain barrier of the body. Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

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Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

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Answer 3

Question

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Expert Solution & Answer

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Answer 4

Question

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Expert Solution & Answer

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Answer 5

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Answer 6

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Answer 7

Chapter 9, Problem 9RQ

Summary Introduction

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Answer 8

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Answer 9

Summary Introduction

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Answer 10

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Answer 11

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Answer 13

Ch. 9.2 - Prob. 1CC Ch. 9.3 - Name the four kinds of glial cells found in the...Ch. 9.3 - Prob. 3CC Ch. 9.3 - Prob. 4CC Ch. 9.3 - Prob. 5CC Ch. 9.3 - Prob. 6CC Ch. 9.3 - Prob. 7CC Ch. 9.3 - Prob. 8CC Ch. 9.3 - Prob. 9CC Ch. 9.3 - In the late 1800s, the scientist Paul Ehrlich...

The blood-brain barrier of the body. Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Solution Summary: The author explains the function of the blood-brain barrier, which protects the brain from harmful toxins.

Concept explainers

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Want to see the full answer?

Chapter 9 Solutions

The blood-brain barrier of the body. Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

Solution Summary: The author explains the function of the blood-brain barrier, which protects the brain from harmful toxins.

Concept explainers

To determine: The blood-brain barrier of the body. Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

To determine: The function of blood-brain barrier. Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.

Want to see the full answer?

Chapter 9 Solutions

To determine: The blood-brain barrier of the body.

Introduction: The nervous system of humans is composed of CNS and PNS. CNS stands for “Central nervous system” and it is composed of the brain and the spinal cord. The brain is the most important organ of the body.

To determine: The function of blood-brain barrier.

Introduction: The heart supplies oxygen to the brain by the help of blood vessels. The blood vessels that carry blood to the brain and protect the brain are called blood-brain carriers. They are important for the normal functioning of the brain.